TABLE 3.
Recovery of C. immitis from the brains and spinal cords of rabbits
| Block and treatment (dose [mg/kg]) | No. of animals cured/total no. in group | Log10 geometric mean no. of CFU/g of spinal cord | Fold reduction in no. of CFU in spinal cord that for versus controla | Log10 geometric mean no. of CFU/g of brain tissue. | Fold reduction no. of CFU in brain versus that for control |
|---|---|---|---|---|---|
| Block 1 | |||||
| D5W | 0/8 | 3.67 (2.22-5.13, 0)b | 2.78 (1.33-4.24, 0) | ||
| FLC (80) | 0/10 | 1.45 (0.15-2.75, 1) | 166 | 0.92 (0-2.23, 2) | 72 |
| AmBi (15) | 3/8 | 0.42 (0-1.87, 5) | 1,778 | 0.46 (0-1.95, 4) | 209 |
| Block 2 | |||||
| D5W | 0/8 | 4.14 (3.92-4.36, 0) | 3.61 (3.38-3.83, 0) | ||
| AmB (1) | 0/8 | 2.43 (2.13-2.69, 0) | 51 | 2.06 (1.83-2.28, 0) | 35 |
| Block 3 | |||||
| D5W | 0/8 | 3.47 (3.07-3.87, 0) | 2.93 (2.34-3.52, 0) | ||
| AmBi (7.5) | 0/8 | 1.56 (0.94-2.17, 1) | 81 | 1.18 (0.66-1.70, 1) | 56 |
| AmBi (22.5) | 0/8 | 1.44 (0.65-2.22, 2) | 107 | 1.11 (0.80-1.41, 0) | 66 |
a
The fold reductions in CFU were determined by subtracting the log10 geometric number of CFU for the treatment group from the log10 geometric number of CFU for the D5W control group in the same block. The antilog of the resulting number was taken to give the arithmetic fold reduction.
b
The values in parentheses are 95% confidence intervals, numbers of animals free of infection.