TABLE 2.
Mean concentration of clarithromycin and 14-hydroxyclarithromycin in serum at two different dosages after the second day
| Time (h) postdose | Mean concn (μg/ml)a ± SD in:
|
|||
|---|---|---|---|---|
| Uninfected rabbits fed cholesterol-enriched dietb (n = 4)
|
Infected rabbits on normal chowc (n = 4)
|
|||
| CLA | 14-HCLA | CLA | 14-HCLA | |
| 4 | 0.534 ± 0.269 | 0.271 ± 0.326 | 0.168 ± 0.084 | 0.126 ± 0.078 |
| 12 | 0.172 ± 0.138 | 0.03 ± 0.17 | 0.010 ± 0.007 | 0.011 ± 0.011 |
| 24 | <0.01 | <0.01 | <0.01 | <0.01 |
a
CLA, clarithromycin; 14-HCLA, 14-hydroxyclarithromycin.
b
At dose of 30 mg/kg/day.
c
At dose of 20 mg/kg/day.