TABLE 1.
Antimicrobial agent and penicillin susceptibility statusa | MIC (μg/ml)g
|
% of isolatesb:
|
|||||
---|---|---|---|---|---|---|---|
Range | 50% | 90% | Mode | S | I | R | |
Penicillin | |||||||
All | ≤0.06->32 | ≤0.06 | 2 | ≤0.06 | 64.6 | 19.3 | 16.2 |
Pen-S | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | 100 | 0 | 0 |
Pen-I | 0.12-1 | 0.5 | 1 | 1 | 0 | 100 | 0 |
Pen-R | 2->32 | 2 | 4 | 2 | 0 | 0 | 100 |
Amoxicillin-clavulanatec | |||||||
All | ≤0.03-16 | ≤0.03 | 2 | ≤0.03 | 77.9 (94.6) | 9.9 (3.4) | 12.2 (2.0) |
Pen-S | ≤0.03-0.25 | ≤0.03 | ≤0.03 | ≤0.03 | 100 (100) | 0 (0) | 0 (0) |
Pen-I | ≤0.03-8 | 0.5 | 1 | 0.5 | 68.3 (98.5) | 23.2 (1.3) | 8.5 (0.2) |
Pen-R | 0.5-16 | 2 | 8 | 2 | 0.9 (68.4) | 33.5 (19.7) | 65.6 (11.9) |
Cefuroxime | |||||||
All | ≤0.25->16 | ≤0.25 | 8 | ≤0.25 | 70.1 | 1.9 | 28.1 |
Pen-S | ≤0.25-4 | ≤0.25 | ≤0.25 | ≤0.25 | 99.8 | 0.1 | 0.0d |
Pen-I | ≤0.25->16 | 2 | 4 | 4 | 29.1 | 9.3 | 61.6 |
Pen-R | 2->16 | 8 | 16 | 8 | 0 | 0 | 100 |
Ceftriaxonee | |||||||
All | ≤0.03-16 | ≤0.03 | 1 | ≤0.03 | 82.7 (96.4) | 13.7 (2.1) | 3.6 (1.5) |
Pen-S | ≤0.03-0.5 | ≤0.03 | 0.06 | ≤0.03 | 100 (100) | 0 (0) | 0 (0) |
Pen-I | ≤0.03-4 | 0.5 | 1 | 0.5 | 89.7 (99.3) | 9.6 (0.6) | 0.7 (0.1) |
Pen-R | 0.5-16 | 1 | 2 | 1 | 8.1 (78.6) | 73.5 (12.4) | 21.4 (9.0) |
Azithromycin | |||||||
All | ≤0.06->32 | ≤0.06 | 6 | ≤0.06 | 74.9 | 3.7 | 21.4 |
Pen-S | ≤0.06->32 | ≤0.06 | ≤0.12 | ≤0.06 | 94.5 | 0.7 | 4.8 |
Pen-I | ≤0.06->32 | 1 | >32 | ≤0.06 | 49.8 | 7.9 | 42.3 |
Pen-R | ≤0.06->32 | 2 | >32 | >32 | 26.7 | 11.0 | 62.3 |
SXT | |||||||
All | ≤0.03->4 | 0.25 | >4 | 0.25 | 63.3 | 6.5 | 30.3 |
Pen-S | ≤0.03->4 | 0.25 | 1 | 0.25 | 86.7 | 5.3 | 8.1 |
Pen-I | 0.06->4 | 4 | >4 | >4 | 33.0 | 11.0 | 56.0 |
Pen-R | 0.06->4 | 4 | >4 | >4 | 5.9 | 5.9 | 88.2 |
Levofloxacin | |||||||
All | ≤0.008-32 | 0.5 | 1 | 0.5 | 99.3 | 0.1 | 0.6 |
Pen-S | ≤0.008-16 | 0.5 | 1 | 0.5 | 99.3 | 0.1 | 0.6 |
Pen-I | 0.25-16 | 0.5 | 1 | 0.5 | 99.4 | 0 | 0.6 |
Pen-R | 0.25-32 | 0.5 | 1 | 0.5 | 99.0 | 0.1 | 0.9 |
Moxifloxacinf | |||||||
All | ≤0.008-4 | 0.12 | 0.12 | 0.12 | 99.5 | 0.4 | 0.1 |
Pen-S | ≤0.008-4 | 0.12 | 0.12 | 0.12 | 99.5 | 0.5 | 0.1 |
Pen-I | 0.03-4 | 0.12 | 0.12 | 0.12 | 99.7 | 0.2 | 0.1 |
Pen-R | 0.06-4 | 0.12 | 0.12 | 0.12 | 99.2 | 0.5 | 0.3 |
Vancomycin | |||||||
All | ≤0.12-1 | 0.25 | 0.5 | 0.25 | 100 | -h | - |
Pen-S | ≤0.12-1 | 0.25 | 0.5 | 0.25 | 100 | - | - |
Pen-I | ≤0.12-1 | 0.25 | 0.5 | 0.25 | 100 | - | - |
Pen-R | ≤0.12-1 | 0.25 | 0.5 | 0.25 | 100 | - | - |
A total of 3,189 isolates were penicillin susceptible (Pen-S), 952 were penicillin intermediate (Pen-I), and 799 were penicillin resistant (Pen-R).
S, susceptible; I, intermediate; R, resistant.
NCCLS 1999 breakpoints (16) were used to interpret data for amoxicillin-clavulanate. Interpreted data utilizing NCCLS 2002 breakpoints (18) are shown in parentheses.
Actual percent resistance was 0.02%.
NCCLS 1999 breakpoints (16) were used to interpret data for ceftriaxone. Interpreted data utilizing NCCLS 2002 interpretations (18) are shown in parentheses.
NCCLS 2002 breakpoints (18) were used to interpret data for moxifloxacin.
50% and 90%, MIC50 and MIC90, respectively.
-, no NCCLS criteria (18) available for I and R category intrepretations.