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Amino acid sequences of the penicillin-binding domain of the PBP 2X (a), PBP 2B (b), and PBP 1A (c) proteins. Row 1, the sequence from penicillin-susceptible strain R6. The conserved amino acid motifs are underlined and set in boldface type. Rows 2 through 7, isolates 73202, 72521, 73311, 18062, 60702, and 9481, respectively. Only those amino acids that differ from the R6 sequence are shown. Amino acids are numbered according to their positions in the gene.
