aBMD	areal Bone Mineral Density
Akt	Protein kinase B
BMD	Bone Mineral Density
CI	Confidence Interval
DXA	Dual-energy X-ray Absorptiometry
ERα	Estrogen Receptor α
ERβ	Estrogen Receptor β
HR	Hazard Ratio
HR-pQCT	High-Resolution Peripheral Quantitative Computed Tomography
MrOS	Osteoporotic Fractures in Men Study
Nrf2	Nuclear factor erythroid 2–related factor 2
OPG	Osteoprotegerin
PI3K	Phosphoinositide 3-kinase
RCT	Randomized Controlled Trial
RANKL	Receptor Activator of Nuclear Factor-κB Ligand
SD	Standard Deviation
SERM	Selective Estrogen Receptor Modulator
vBMD	volumetric Bone Mineral Density
WHI	Women’s Health Initiative