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Release of pyridine from ceftazidime upon incubation at 4°C (□), 25°C (▨), and 37°C (▪) at two different initial concentrations (left panel, 8.3% [wt/vol]; right panel, 12% [wt/vol]). Freshly prepared samples contained <0.1 mg of pyridine/ml. The dotted line indicates the upper limit allowed for pyridine content in ceftazidime solutions according to the U.S. Pharmacopeia (39).
