TABLE 1.

Sensitivity of HCMV strain AD169 to benzimidazole ribosides and GCV in MRC-5 lung fibroblast cells

Test compound			Mean IC50 (μM) ± SEMa as determined by:
Name	Benzimidazole 2-substituent	Ribose configuration	DNA hybridization	Plaque reduction	Yield reduction
1263W94	2-Isopropylamino	l	0.12 ± 0.01 (71)	0.54 ± 0.05 (10)	0.06 ± 0.018 (4)
3322W93	2-Isopropylamino	d	2.3 ± 0.5 (3)	7.5 (1)	1.3 ± 0.3
3858U92	2-Bromo	l	0.9 ± 0.2 (5)	1.3 ± 0.7 (3)	0.5 ± 0.06
BDCRB	2-Bromo	d	0.54 ± 0.08 (20)	0.31 ± 0.06 (6)	0.018 ± 0.001
GCV	NAb	Acyclic	0.53 ± 0.04 (117)	6.3 ± 0.7 (6)	0.30 ± 0.15 (2)

^aThe number of experiments is shown in parentheses.

^bNA, not applicable.