TABLE 2.
Susceptibility of HCMV clinical isolates to 1263W94 and GCVa
| Virus strain | Mean IC50 (μM) as determined by:
|
|||
|---|---|---|---|---|
| DNA hybridization assay
|
Plaque reduction assay
|
|||
| 1263W94 | GCV | 1263W94 | GCV | |
| AD169 | 0.04 | 0.40 | 0.97 | 4.30 |
| C8301 | 0.04 | 0.25 | 0.12 | 1.10 |
| C8501 | 0.10 | 1.00 | 0.34 | 1.00 |
| C8910 | 0.12 | 0.70 | 0.19 | 1.40 |
| C9207 | 0.03 | 0.15 | 0.44 | 6.70 |
| C8303 | 0.09 | 0.80 | 0.54 | 0.80 |
| C8302 | 0.10 | 0.30 | 0.16 | 2.70 |
| C8803 | 0.13 | 0.70 | 0.21 | 3.40 |
| C8912 | 0.04 | 0.50 | 0.21 | 2.60 |
| C9003 | 0.12 | 1.10 | 0.56 | 1.00 |
| C9213 | 0.04 | 0.40 | 0.40 | 7.00 |
a
Assays were performed with HCMV-infected MRC-5 lung fibroblast cells. Values represent the average of two independent determinations. The standard error of the mean was <30% of the value shown in all assays.