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Cytotoxicity of benzimidazole ribosides and GCV to primary human bone marrow progenitor cellsa
| Test compound | Mean IC50 (μM) ± SEM
|
||
|---|---|---|---|
| CFU-GM | BFU-E | No. of determinations (no. of donors) | |
| 1263W94 | 90 ± 4 | 88 ± 4 | 4 (4) |
| BDCRB | 110 ± 18 | 90 ± 10 | 9 (9) |
| GCV | 15 ± 3 | 39 ± 10 | 18 (15) |
Data for 1263W94 were previously reported by Chan et al. (5). CFU-GM, CFU of granulocytes-macrophages; BFU-E, burst-forming unit-erythroid.
