TABLE 6.
Relationships between pharmacodynamic parameters and residual OPC score at day 15a
| Parameter | Emax | EP50 | Gamma | r (observed/ predicted) | P |
|---|---|---|---|---|---|
| AUC0-12b | 7.53 ± 0.77 | 2.57 ± 0.58 | 4.56 ± 4.01 | 0.595 | 0.01 |
| AUC0-12/MICc | 7.15 ± 0.85 | 0.76 ± 0.65 | NA | 0.483 | 0.02 |
| Cmaxb | 7.61 ± 0.79 | 0.401 ± 0.15 | 1.91 ± 1.32 | 0.584 | 0.01 |
| Cmax/MICc | 7.19 ± 0.81 | 0.214 ± 0.18 | NA | 0.530 | 0.01 |
| Cminb | 7.06 ± 0.72 | 0.156 ± 0.09 | 9.90 ± 32.1 | 0.571 | 0.01 |
| Cmin/MICc | 6.94 ± 0.80 | 0.086 ± 0.07 | NA | 0.505 | 0.02 |
| Tτ ≥ MICc | 6.21 ± 0.73 | 0.202 ± 0.92 | NA | 0.419 | 0.05 |
a
Emax, maximum effect; EP50, 50% effect parameter value; gamma, slope of the central part of the curve; NA, not applicable. Emax, EP50, and gamma values are given as means and SEMs.
b
The equation for the inhibitory effect sigmoidal pharmacodynamic model is Emax{1 − [Cgamma/(Cgamma + EP50gamma)]}, where C is the pharmacodynaic parameter.
c
The equation for the inhibitory effect pharmacodynamic model is Emax{1 − [C/(C + EP50)]}, where C is the pharmacodynamic parameter.