FIG. 1.

Cumulative mortality of 12 guinea pigs per treatment group treated with caspofungin (CAS), voriconazole (VRC), caspofungin plus voriconazole, or amphotericin B (AmB). Guinea pigs were challenged on the second day. Controls (□) received no antifungal therapy. Treatment of the guinea pigs with amphotericin B at 1.25 mg/kg/day (▵), caspofungin at 1 mg/kg/day (▪) or 2.5 mg/kg/day (▴), voriconazole at 5 mg/kg/day (⋄), caspofungin at 1 mg/kg/day plus voriconazole at 5 mg/kg/day (*), or caspofungin at 2.5 mg/kg/day plus voriconazole at 5 mg/kg/day (•) was initiated 24 h after challenge and was given daily for 5 days.