TABLE 1.
Mean times of survival in temporarily immunosuppressed guinea pigs
| Group (dose [mg/kg/day])a | Mortality (no. of animals that died/total no. of animals tested) [% of total]) | Mean survival time (days)b
|
|
|---|---|---|---|
| Mean ± SE | Range | ||
| Control | 12/12 (100) | 4.5 ± 0.29 | 3-6 |
| Caspofungin | |||
| 2.5 | 6/12 (50)c | 6.83 ± 0.37c | 5-8 |
| 1 | 4/12 (33)c | 7.33 ± 0.31c | 5-8 |
| Caspofungin (2.5) + voriconazole (5) | 0/12 (0)c | 8c | 8 |
| Caspofungin (1) + voriconazole (5) | 0/12 (0)c | 8c | 8 |
| Voriconazole (5) | 0/12 (0)c | 8c | 8 |
| Amphotericin B | 3/12 (25)c | 7.08 ± 0.50c | 3-8 |
a
There were 12 animals in each group.
b
Time of survival from day of challenge with A. fumigatus.
c
P < 0.0025 compared to controls.