TABLE 2.
Results of semiquantitative cultures of organs from guinea pigs treated with antifungal agents beginning 24 h after challenge and killed 96 h after completion of therapy
| Group (dose [mg/kg/day])a | Colony count (mean ± SE log10CFU/g of tissue)
|
|||
|---|---|---|---|---|
| Liver | Lung | Kidney | Brain | |
| Control | 3.32 ± 0.20 | 0.90 ± 0.22 | 3.11 ± 0.19 | 3.03 ± 0.23 |
| Caspofungin | ||||
| 2.5 | 3.19 ± 0.45 | 0.42 ± 0.13 | 1.64 ± 0.31b | 2.97 ± 0.40 |
| 1 | 1.93 ± 0.48b | 0.56 ± 0.23 | 1.42 ± 0.39b | 1.47 ± 0.45 |
| Caspofungin (2.5) + voriconazole (5) | 0.32 ± 0.20b | 0.11 ± 0.08b | 0.34 ± 0.19b | 0.13 ± 0.11b |
| Caspofungin (1) + voriconazole (5) | 0.08 ± 0.04b | 0.05 ± 0.04b | 0.13 ± 0.11b | 0.19 ± 0.20b |
| Voriconazole (5) | 0.35 ± 0.19b | 0.30 ± 0.07 | 0.58 ± 0.19b | 0.13 ± 0.09b |
| Amphotericin B | 1.22 ± 0.37b | 0.38 ± 0.17 | 0.98 ± 0.32b | 0.87 ± 0.44b |
a
There were 12 animals in each group.
b
P < 0.0025 compared to controls.