TABLE 3.
Group (dose [mg/kg/day])a | No. of positive cultures/no. of guinea pig organs cultured
|
||||
---|---|---|---|---|---|
Liver | Lung | Kidney | Brain | Any organ | |
Control | 12/12 | 12/12 | 12/12 | 12/12 | 12/12 |
Caspofungin | |||||
2.5 | 11/12 | 10/12 | 10/12 | 9/12 | 12/12 |
1 | 12/12 | 8/12 | 9/12 | 7/12 | 12/12 |
Caspofungin (2.5) + voriconazole (5) | 3/12b | 2/12b | 4/12b | 2/12b | 5/12b |
Caspofungin (1) + voriconazole (5) | 3/12b | 2/12b | 2/12b | 1/12b | 3/12b |
Voriconazole 5 | 6/12 | 8/12 | 8/12 | 3/12b | 12/12 |
Amphotericin B | 8/12 | 6/12 | 8/12 | 4/12b | 11/12 |
There were 12 animals in each group
P < 0.0025 compared to controls.