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. 2002 Aug;46(8):2564–2568. doi: 10.1128/AAC.46.8.2564-2568.2002

TABLE 3.

Results of cultures of organs from temporarily immunosuppressed guinea pigs killed 96 h after completion of therapy

Group (dose [mg/kg/day])a No. of positive cultures/no. of guinea pig organs cultured
Liver Lung Kidney Brain Any organ
Control 12/12 12/12 12/12 12/12 12/12
Caspofungin
    2.5 11/12 10/12 10/12 9/12 12/12
    1 12/12 8/12 9/12 7/12 12/12
Caspofungin (2.5) + voriconazole (5) 3/12b 2/12b 4/12b 2/12b 5/12b
Caspofungin (1) + voriconazole (5) 3/12b 2/12b 2/12b 1/12b 3/12b
Voriconazole 5 6/12 8/12 8/12 3/12b 12/12
Amphotericin B 8/12 6/12 8/12 4/12b 11/12
a

There were 12 animals in each group

b

P < 0.0025 compared to controls.