TABLE 3.

Activities of GCV, CDV, cCDV, and alkoxyalkyl esters of CDV and cCDV against HCMV replication measured by plaque reduction assay

Isolatea	EC50 (μM)b
	GCV	CDV	HDP-CDV	ODE-CDV	cCDV	HDP-cCDV	ODE-cCDV
AD169	2.75 ± 1.6	0.38 ± 0	0.0009 ± 0.0001	0.0009 ± 0.0001	0.31 ± 0.02	0.001 ± 0	0.0018 ± 0.001
Towne	4.3 ± 0	0.4 ± 0.11	0.0009 ± 0	0.0009 ± 0.0001	0.48 ± .02	0.001 ± 0	0.001 ± 0
Davis	5.1 ± 0	0.66 ± 0.3	0.00095 ± 0.00007	0.0009 ± 0.0001	0.45 ± 0.07	0.001 ± 0	0.001 ± 0
Toledo	19.6 ± 7.2	13.8 ± 7.3	0.025 ± 0.007	0.025 ± 0.02	17.1 ± 8	0.055 ± 0.03	0.055 ± 0.03
Coffman	4.7 ± 0	0.87 ± 0.15	0.001 ± 0	0.001 ± 0	1.2 ± 0.5	0.0015 ± 0.0007	0.002 ± 0.0007
C8708/17-1-1	2.6 ± 0.9	1.1 ± 0.5	0.001 ± 0	0.001 ± 0	2.1 ± 0.4	0.0015 ± 0.0007	0.0025 ± 0.002
C9208/3-3-1	4.25 ± 1.2	0.95 ± 0.6	0.001 ± 0	0.001 ± 0	1.3 ± 0.3	0.00095 ± 0.00007	0.001 ± 0
C9208/5-4-2	1.6 ± 0.42	0.41 ± 0.09	0.00085 ± 0.0002	0.001 ± 0	1.1 ± 0.26	0.00095 ± 0.00007	0.001 ± 0

^aAll isolates are wild type.

^bThe values are the means ± standard deviations of two or more determinations.