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RNase L−/− mice were immunized with either BCG, pVax-85B, or Sin85B and then challenged aerogenically with virulent M. tuberculosis Erdman. Twenty-eight days postchallenge, the lungs were removed and lung snips were fixed with formalin and stained with Ziehl-Neelsen acid-fast stain. Naive mice served as controls. Magnification, ×186.
