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Maintenance of vaccine induced resistance by CD4 and CD8 cells in the absence of CD28. Mice were vaccinated subcutaneously twice with 106 live yeast at each site of injection. After a resting period of 3 months, mice were infected intratracheally with 2 × 103 wild-type yeast. The data are geometric mean CFU ± the standard error of the mean; n = six to nine mice/group. *, P < 0.001 (versus unvaccinated control mice).
