FIG. 7.

(A) Effects of poly(vinylsulfonate sodium salt) I (compound 1; 4.8 mg/dose) administered either before or after parasite inoculation on the time course of P. berghei parasitemia, expressed as the numbers of intracellular parasites/100 RBCs. Parasites were inoculated i.p., and treatment with compound 1 was started either 24 h before or 24 h after inoculation. Compound 1 was given i.p. at 12-h intervals for a period of 10 days. •, no treatment; ▪, treatment with compound 1 starting 24 h after inoculation; ▾, treatment with compound 1 starting 24 h after inoculation and ending after day 7; ▴, treatment with compound 1 starting 24 h before inoculation. Each point is the mean ± standard error of the mean for eight animals per time point. An ANOVA of between-group comparisons revealed significant differences (P < 0.001). (B) Effects of different doses of poly(vinylsulfonate sodium salt) II (compound 2) on the time course of P. berghei parasitemia, expressed as the numbers of intracellular parasites/100 RBCs. Parasites were inoculated i.p., and treatment with compound 2 was started 24 h later. Each dose of compound 2 was given i.p. at 12-h intervals for a period of 9 days. •, no treatment; ▾, treatment with a dose of 125 μg; ▴, treatment with a dose of 500 μg; ▪, treatment with a dose of 2 mg. The highest dose proved to have an adverse effect on animal well-being, and these animals were euthanized after 8 days. Each point is the mean ± standard error of the mean for eight animals per time point. An ANOVA of between-group comparisons revealed significant differences (P < 0.001).