Cross-reactivity of total Igs, IgM, and IgG1 antibodies against histone, TNP-BSA, DNA, and collagen III elicited in mice primed or not primed with heat-killed M. vaccae followed by boosting twice with MTB70. Antibody responses were measured from pooled sera of three mice per group. The sera were diluted in consecutive twofold dilutions, starting from 1:20 up to 1:640. ODs from 1:160 dilutions are presented here.