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Loss of TLR4-mediated signals during yeast-to-hypha transition of C. albicans. Recognition of C. albicans blastoconidia involves both TLR2 and TLR4. The yeast-to-hypha transition results in the loss of proinflammatory TLR4-mediated signals and a TLR2-mediated anti-inflammatory cytokine profile, used by C. albicans as an escape mechanism from the host defense.
