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Susceptibility of C57BL/6 mice to Y. pestis strain KIM D27. C57BL/6 mice were intraperitoneally (i.p.) (A) or intranasally (i.n.) (B) infected with the indicated number of Y. pestis KIM D27 CFU and monitored daily for survival. An intraperitoneal dose of 3 × 102 CFU was chosen as a sublethal inoculum for generating convalescent-phase sera. An intranasal dose of 2 × 105 CFU was chosen for lethal challenge experiments.
