FIG. 6.
Adoptive transfer of Y. pestis-primed T cells protects naive μMT mice against lethal intranasal Y. pestis infection. Cells isolated from B-cell-deficient μMT mice that had been vaccinated and challenged as described for Fig. 3 were stimulated in vitro with heat-killed Y. pestis, expanded with IL-2, and transferred to naive μMT mice as described in Materials and Methods. The next day, the mice were intranasally challenged with 2 × 105 CFU Y. pestis KIM D27. A significantly greater number of mice that received T cells survived the infection (n = 10 per group; P = 0.01). Data are pooled from two independent experiments.