TABLE 1.
Results for chloroquine-azithromycin combinationa
| Source | Parasite clone | Sum (1:1 ratio)b
|
IC50 (ng/ml) of:
|
||
|---|---|---|---|---|---|
| FIC50s | FIC90s | Chloroquine | Azithromycin | ||
| Sierra Leone | D6c | 1.02 ± 0.19 | 1.24 ± 0.16 | 3.5 ± 3.5 | 5,499.3 ± 2,944.0 |
| Kenya | MFc | 1.18 ± 0.17 | 1.12 ± 0.03 | 4.0 ± 1.1 | 7,763.0 ± 3,544.0 |
| KS021 | 0.63 ± 0.02 | 0.55 ± 0.22 | 15.2 ± 3.4 | 2,229.5 ± 499.9 | |
| Thailand | C2A | 0.68 ± 0.10 | 0.62 ± 0.15 | 27.0 ± 7.6 | 827.2 ± 132.6 |
| C2B | 0.78 ± 0.02 | 0.64 ± 0.09 | 29.7 ± 10.4 | 741.0 ± 394.6 | |
| Indonesia | I3 | 0.78 ± 0.01 | 1.01 ± 0.53 | 34.2 ± 5.0 | 3,586.5 ± 1,518.2 |
| A8I21 | 0.90 ± 0.13 | 0.69 ± 0.17 | 39.7 ± 9.2 | 5,328.0 ± 2,261.7 | |
| I14 | 0.88 ± 0.17 | 0.99 ± 0.18 | 55.3 ± 9.9 | 4,991.0 ± 1,128.5 | |
| A9123 | 0.86 ± 0.01 | 0.76 ± 0.12 | 65.9 ± 14.3 | 10,207.0 ± 4,594.8 | |
| Vietnam | W2 | 0.89 ± 0.26 | 0.71 ± 0.31 | 57.9 ± 14.4 | 620.4 ± 595.3 |
a
Values are reported as means and standard deviations for assays run in duplicate on different days.
b
Synergy, <1; additivity, 1; antagonism, >1.
c
Chloroquine sensitive; 10 ng/dl is the cutoff in our laboratory.