FIG. 1.
Decreased susceptibility to systemic C. albicans infection in GITR−/− mice. GITR+/+ and GITR−/− mice were intravenously infected with 5 × 105 C. albicans cells. A: Survival was assessed daily for 40 days. % survival of infected mice was evaluated according to Mantel-Cox Logrank test and the difference between GITR−/− and GITR+/+ mice resulted significant (P < 0.01). B: For the quantification of fungal burden, mice were sacrificed 2 and 6 days after infection, serial dilutions of organ homogenates were plated onto Sabouraud agar, and CFU were counted after 48 h incubation. Fungal burden is expressed as CFU/organ. Data represent means ± standard error of the mean of data from three independent experiments. **, P < 0.01, GITR−/− versus GITR+/+, according to Student's t test.