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. 2025 May 22;64(23):3447–3452. doi: 10.2169/internalmedicine.5476-25

Table 2.

Summary of Clinical, Imaging, and Histopathological Features of Diseases Presenting with Renal Mass Lesions.

Clinicopathological features Anastomosing hemangioma IgG4-related kidney disease Renal cell carcinoma (RCC)
Frequency Rare Rare Common
Clinical manifestations None or hematuria, flank pain Renal dysfunction, mass lesions, proteinuria Hematuria or bask pain, palpable mass
Histopathology Benign vascular proliferation with anastomosing sinusoidal-like spaces Dense lymphoplasmacytic infiltrate, storiform fibrosis, IgG4-positive plasma cells Malignant epithelial cells forming glandular or solid structures
Immunohistochem-istry CD31, CD34 positive IgG4-positive plasma cells PAX8, RCC marker positive
Radiological findings Hypoattenuation, arterial enhancement on CT Diverse lesions such as wedge-shaped areas Hypervascular mass, often with necrosis on CT/MRI
Treatment Surgical resection Immunosuppressive therapy Surgical resection, targeted therapy, immunotherapy

RCC: Renal cell carcinoma