FIG. 2.
Secondary structures of hairpin 35 in domain II (top) and in domain V (bottom) of 23S rRNA in E. coli. Nucleotides which are protected by erythromycin are circled (43). Arrows indicate mutations conferring macrolide resistance on S. pneumoniae. The corresponding phenotype is indicated (K, ketolides; L, lincosamides; M, macrolides; M16, 16-membered macrolides; SB, streptogramin B; S, streptogramin A and streptogramin B). Small capital letters denote low-level resistance.