TABLE 1.
Macrolide-lincosamide-streptogramin B resistance in S. pneumoniae due to gene acquisition
Gene(s) | Resistance phenotype(s)a | Phenotype forb:
|
Reference | ||||||
---|---|---|---|---|---|---|---|---|---|
14-M and 15-M | K | 16-M | L | SB | SA | SA+B | |||
erm(B) | MLSB (i) | R | S | R | r or R | r or R | S | S | 33 |
MLSB (c) | R | R | R | R | R | S | S | ||
erm(A) | MLSB (c) | R | R | R | R | R | S | S | 38 |
mef(A) | M | R | S | S | S | S | S | S | 39 |
erm(B) + mef(A) | MLSB + M | R | ND | R | R | R | S | S | 23 |
c, constitutive; i, inducible.
14-M, 15-M, and 16-M, 14-, 15-, and 16-membered macrolides, respectively; K, ketolides; L, lincosamides; SB, streptogramin B; SA, streptogramin A; SA+B, streptogramin A and B; r, low-level resistance; R, high-level resistance; S, susceptibility; ND, not determined.