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. 2002 Sep;46(9):2727–2734. doi: 10.1128/AAC.46.9.2727-2734.2002

TABLE 1.

Macrolide-lincosamide-streptogramin B resistance in S. pneumoniae due to gene acquisition

Gene(s) Resistance phenotype(s)a Phenotype forb:
Reference
14-M and 15-M K 16-M L SB SA SA+B
erm(B) MLSB (i) R S R r or R r or R S S 33
MLSB (c) R R R R R S S
erm(A) MLSB (c) R R R R R S S 38
mef(A) M R S S S S S S 39
erm(B) + mef(A) MLSB + M R ND R R R S S 23
a

c, constitutive; i, inducible.

b

14-M, 15-M, and 16-M, 14-, 15-, and 16-membered macrolides, respectively; K, ketolides; L, lincosamides; SB, streptogramin B; SA, streptogramin A; SA+B, streptogramin A and B; r, low-level resistance; R, high-level resistance; S, susceptibility; ND, not determined.

HHS Vulnerability Disclosure