TABLE 2.
MICs of macrolides and related antibiotics for ribosomal mutants of S. pneumoniae selected in vitro
Resistance phenotype | Gene (product) | Alteration(s) | MIC (μg/ml) ofa:
|
Reference(s) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AZM | CLR | ERY | SPI | JOS | TEL | SGB | PRI | CLI | ||||
MLSB | rrl (23S rRNA domain V) | A2058G or A2058U | >32->200 | 16-100 | >32->100 | 6.25 | ND | 0.06-1 | 12.5 | 0.5 | 0.2-4 | 5, 40 |
ML | rrl (23S rRNA domain V) | A2059G | >32 | 2 | 8 | ND | ND | 0.015 | ND | 0.25 | 2 | 5, 40 |
ML (low level) | rrl (23S rRNA domain V) | C2610U | 0.125 | 0.03 | 0.06 | ND | ND | 0.008 | ND | 0.5 | 0.5 | 5 |
MSB | rrl (23S rRNA domain V) | C2611A, C2611G, or C2611U | 0.5-12.5 | 0.06-100 | 0.06->100 | 0.78-1.56 | ND | 0.01-0.39 | 50->100 | 0.5 | 0.2-2 | 5, 40 |
MKLSB | rrl (23S rRNA domain II) | A752 deletion | >32 | >32 | >32 | ND | ND | 4 | ND | 1 | 1 | 5 |
MSB | rplD (L4 protein) | G69C and 67QSQKb | 0.39-1.56 | 0.05-0.2 | 0.05-0.2 | ND | 0.78-1.56 | 0.006-0.1 | 3.12 | ND | 0.05-0.2 | 40 |
MS | rplV (L22 protein) | G95D, P99Q, A93E, P91S, and G83E | 0.06-1 | 0.125-1 | 0.25-1 | ND | ND | 0.06-0.25 | ND | 1-2 | 0.03-0.12 | 5 |
AZM, azithromycin; CLR, clarithromycin; ERY, erythromycin; SPI, spiramycin; JOS, josamycin, TEL, telithromycin; SGB, streptogramin B; PRI, pristinamycin IA; CLI, clindamycin. ND, not determined.
The alteration is underlined.