TABLE 3.
MICs of macrolides and related antibiotics for ribosomal mutants of clinical isolates of S. pneumoniae
Product | Mutation | No. of isolates | MIC (μg/ml) ofa:
|
Reference(s) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AZM | CLR | ERY | SPI | JOS | TEL | QUI | PRI or Q-D | CLI | ||||
23S rRNA domain V (no. of mutated copies) | A2059G (2 or 3) | 5 | >100->512 | 12.5->512 | 50->100 | 512 | >100 | 0.01-0.25 | 3.12-32 | 2-4 | 0.78-2 | 29, 41 |
A2059C (2 to 4) | 7 | 128-512 | 512->512 | 256->512 | 512->512 | ND | 0.06-0.12 | 16-32 | 1-2 | 1-2 | 29 | |
A2062C (4) | 1 | 0.5 | ND | <0.25 | 512 | 64 | <0.0075 | 32 | 2 | <0.015 | 10 | |
C2611G (4) | 1 | 128 | >512 | >512 | 16 | ND | 0.5 | >64 | 2 | 1 | 29 | |
L4 protein | 69TPS71 | 17 | >100->512 | 12.5->512 | >100->512 | 64 | 100 | 0.03-0.2 | 12.5-25 | 2 | 0.05-0.2 | 29, 41 |
Insertion (71GREKGTGR72)b | 1 | 12.5 | 12.5 | 6.25 | ND | 6.25 | 3.12 | 25 | ND | 0.05 | 41 | |
L22 protein | Duplication (102KRTAHITRTAHITVA116)b | 1 | >1 | ND | >1 | ND | ND | ND | ND | >1 | ND | 25 |
QUI, quinupristin; Q-D, quinupristin-dalfopristin; see Table 2, footnote b, for other definitions.
The mutation is underlined.