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. 2002 Sep;46(9):2727–2734. doi: 10.1128/AAC.46.9.2727-2734.2002

TABLE 3.

MICs of macrolides and related antibiotics for ribosomal mutants of clinical isolates of S. pneumoniae

Product Mutation No. of isolates MIC (μg/ml) ofa:
Reference(s)
AZM CLR ERY SPI JOS TEL QUI PRI or Q-D CLI
23S rRNA domain V (no. of mutated copies) A2059G (2 or 3) 5 >100->512 12.5->512 50->100 512 >100 0.01-0.25 3.12-32 2-4 0.78-2 29, 41
A2059C (2 to 4) 7 128-512 512->512 256->512 512->512 ND 0.06-0.12 16-32 1-2 1-2 29
A2062C (4) 1 0.5 ND <0.25 512 64 <0.0075 32 2 <0.015 10
C2611G (4) 1 128 >512 >512 16 ND 0.5 >64 2 1 29
L4 protein 69TPS71 17 >100->512 12.5->512 >100->512 64 100 0.03-0.2 12.5-25 2 0.05-0.2 29, 41
Insertion (71GREKGTGR72)b 1 12.5 12.5 6.25 ND 6.25 3.12 25 ND 0.05 41
L22 protein Duplication (102KRTAHITRTAHITVA116)b 1 >1 ND >1 ND ND ND ND >1 ND 25
a

QUI, quinupristin; Q-D, quinupristin-dalfopristin; see Table 2, footnote b, for other definitions.

b

The mutation is underlined.

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