Table 1.
The twenty pairs of cancer types with the highest ratio of observed (O) to expected (E) number of associated genes. The O/E ratio and a 95% confidence interval (95%CI) are provided. Results are based on cancers mentioned in Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/omim/) searched September 30, 2004.
| Pair of Cancer Types | Number of Genes Related to Both | O/E Ratio and 95%CI | |
| Observed (O) | Expected (E) | ||
| cervix – larynx | 2 | 0.16 | 12.6 ± 4.9 |
| larynx – mouth | 2 | 0.17 | 11.6 ± 4.8 |
| larynx – uterus | 2 | 0.25 | 7.9 ± 3.9 |
| esophagus – stomach | 21 | 2.80 | 7.5 ± 1.2 |
| larynx – stomach | 3 | 0.44 | 6.9 ± 3.0 |
| bladder – esophagus | 10 | 1.51 | 6.6 ± 1.6 |
| larynx – myeloma | 1 | 0.15 | 6.6 ± 5.1 |
| larynx – esophagus | 1 | 0.16 | 6.2 ± 4.9 |
| cervix – esophagus | 6 | 1.02 | 5.9 ± 1.9 |
| bladder – cervix | 8 | 1.47 | 5.4 ± 1.6 |
| cervix – uterus | 8 | 1.59 | 5.1 ± 1.6 |
| larynx – bladder | 1 | 0.23 | 4.3 ± 4.1 |
| pancreas – stomach | 23 | 6.10 | 3.8 ± 0.8 |
| cervix – stomach | 10 | 2.74 | 3.7 ± 1.2 |
| esophagus – mouth | 4 | 1.11 | 3.6 ± 1.9 |
| brain – kidney | 19 | 5.39 | 3.5 ± 0.8 |
| bladder – testis | 18 | 5.12 | 3.5 ± 0.9 |
| bladder – prostate | 17 | 5.05 | 3.4 ± 0.9 |
| bladder – pancreas | 11 | 3.28 | 3.4 ± 1.1 |
| cervix – lung | 20 | 6.14 | 3.3 ± 0.8 |