TABLE 1.
Mean pharmacokinetic parameters for danofloxacin in cattle with respiratory disease following administration either as a single bolus or as a continuous infusion
| Danofloxacin administrationa | Pharmacokinetic parameter (mean [± SD])
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cp0 (ng/ml) | Cmax(obs) (ng/ml) | Cmax(obs): MIC | AUC0-t (ng · h/ml) | AUC0-∞ (ng · h/ml) | AUC:MIC | CLb (ml/h · kg) | T>MIC (h) | λz (h−1) | t1/2b (h) | |
| Single bolus | 589 (±86.7) | 436 (±52.2) | 14.5 (±1.7) | 1,190 (±189) | 1,298 (±195) | 43.3 (±6.5) | 578.2 (±71.3) | 9.1 (±1.6) | 0.16 (±0.02) | 4.3 |
| Continuous infusion | 85.8 (±9.2) | 69.0 (±5.8) | 2.3 (±0.2) | 1,412 (±166) | 1,472 (±177) | 49.1 (±5.9) | 507.8 (±61.5) | 33.3 (±8.3) | 0.31 (±0.08) | 2.3 |
a
Eleven animals in each treatment, but two animals were withdrawn from the infusion treatment for welfare reasons and are only included in the calculation of Cp0, Cmax(obs), and Cmax(obs):MIC.
b
t1/2 was calculated as a harmonic mean.