TABLE 3.
Geometric mean M. haemolytica counts in bronchial secretions and lung tissue samples
| Treatment |
M. haemolytica count (CFU/ml) in bronchial secretions at time (h)a:
|
M. haemolytica count in lung tissue (CFU/g) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 6 | 12 | 18 | 24 | 36 | 48 | ||
| Saline | 2.0 | 1.2 × 103 | 1.6 × 105 | 4.4 × 105 | 1.6 × 107 | 1.8 × 107 | 1.3 × 106 | 2.3 × 107 | 1.9 × 104 |
| Danofloxacin (single bolus) | 0 | 0b | 0b | 0b | 0b | 0b | 0b | 6.1b | 0b |
| Danofloxacin (continuous infusion) | 0 | 0b | 2.7b | 0b | 1.2b | 0.8b | 4.3b | 9.1b | 5.6b |
a
Treatment commenced at time zero.
b
Significantly different from the value obtained with the saline treatment (P < 0.05).