Table 3.
Paralogous gene families expanded in DR
| Description | COG numbers | Number of representatives in DR | Number of representatives in TT |
| Widespread families expanded in DR | |||
| MutT-like phosphohydrolases (Nudix) | COG0494, COG1051 | 17,5 | 5,5 |
| Calcineurin-like phosphoesterase | COG1768, COG1408, COG1692, COG0639 | 1; 1; 1; 9 | 1; 0; 1; 2 |
| Lipase-like alpha/beta hydrolase | COG0596, COG0400 | 10; 1 | 6; 1 |
| Subtilisin-like protease | COG1404 | 10 | 2 |
| Sugar deacetylase | COG2120 | 6 | 4 |
| PadR-like transcriptional regulators (possibly involved in chemical stress response) | COG1695 | 9 | 0 |
| MOSC sulfur-carrier domains | COG2258 | 4 | 1 |
| FlaR like kinases | - | 3 | 0 |
| LigT phosphatases (may participate in RNA repair or methabolism) | - | 3 | 2 |
| McrA endonuclease | COG1403 | 5 | 1 |
| TerZ family (could confer resistance to a variety of DNA-damaging agents) | COG2310 | 7 | 0 |
| PR1 family (stress response) | COG2340 | 5 | 1 |
| DinB family (DNA damage and stress inducible proteins) | COG2318; no COG | 3; 10 | 1 |
| Transcriptional regulators | - | 5 | 0 |
| Unique DR families | |||
| GRXGG repeats containing protein | - | DR0082, DR2593, DR1748 | No |
| Alpha/beta proteins, tryptophan-rich | - | DR2532, DR2457 | No |
| Proteins with GXTXXXG and CXPXXXC motifs (DR0871 has duplication of the domain) | - | DR0871, DR1920, DR2360 | No |
| Secreted alpha/beta proteins with a single conserved domain | - | DR1251, DR1319, DR1545 | No |
| Predominantly alpha-helical proteins | - | DR0481, DR1195, DR1301 | No |
| Predominantly alpha-helical proteins | - | DR0387, DR2038+DR2039 | No |
| Predicted metabolic regulator containing V4R domain | - | DR2179, DR1611 | No |
| Predicted sirohydrochlorin cobaltochelatase | COG2138 | DRA0012, DR2241 | No |
| Conserved histidine rich protein (now also found in Caulobacter and Mesorhizobium) | COG3798 | DR1261, DR1348 | No |