Table 2.
IFP1 Variation and Association with Type 2 Diabetes
| Name | Variat | dbSNP | Posit | Popul | Frequency, Caucasian | Frequency, Af. American | ||
| Cases | Controls | Cases | Controls | |||||
| SNP1 | C/T | ------ | -3766 | AA/Cauc | 0.183 (0.143, 0.223) | 0.192 (0.152, 0.232) | 0.144 (0.118,0.170) | 0.2101 (0.167,0.253) |
| SNP3 | T/C | rs2293942 | -2890 | Cauc | 0.278 (0.232, 0.324) | 0.249 (0.206, 0.292) | ------ | ------ |
| SNP4 | A/T | rs2293943 | -2877 | AA/Cauc | 0.339 (0.291, 0.387) | 0.369 (0.321,0.417) | 0.289 (0.255,0.323) | 0.3702 (0.321,0.419) |
| SNP6 | G/T | ------ | -1263 | AA/Cauc | 0.196 (0.156, 0.236) | 0.189 (0.151, 0.229) | 0.119 (0.091,0.147) | 0.129 (0.093, 0.165) |
| SNP5 | C/T | rs4002827 | -992 | AA | ------ | ------ | 0.071 (0.048, 0.094) | 0.044 (0.021, 0.067) |
| SNP2 | G/A | ------ | -279 | AA/Cauc | 0.458 (0.408, 0.508) | 0.429 0.379, 0.479) | 0.114 (0.086, 0.142) | 0.139 (0.101, 0.177) |
| SNP11 | (G)4/(G)3 | ------ | -108 | AA/Cauc | 0.182 (0.143, 0.221) | 0.177 (0.138, 0.216) | 0.134 (0.108, 0.160) | 0.2173 (0.175, 0.259) |
| SNP8 | G/T | rs4430606 | +918 | AA/Cauc | 0.197 (0.157, 0.237) | 0.191 (0.152, 0.232) | 0.115 (0.087, 0.143) | 0.133 (0.096, 0.170) |
| InsCCG243 | InsCCG | ------ | +4437 | AA | ----- | ----- | 0.091 (0.069, 0.113) | 0.0604 (0.035, 0.085) |
Name, name from Figure 1 and text; variant, major/minor allele except for InsCCG243, in which the insertion is the minor allele; dbSNP, catalog number in public database if available; position, location relative to ATG start; Populat, population in which variant was detected, AA is African American, Cauc is Caucasian; frequency, minor allele frequency. Frequencies are shown with 95% confidence intervals in parentheses. Significance by Fisher Exact test: 1p = 0.007;2p = 0.008; 3p = 0.0008; 4p = 0.088; simulated p values based on 10,000 replicates were 0.027, 0.029, 0.002, and 0.28, for SNP1, SNP4, SNP11, and InsCCG243, respectively. No other simulated p values approached significance.