Table 5.

Haplotypes for 8, 4, and 3 Markers Observed in the African American Population

Variants	No	Haplotype	Case Freq	Control Freq	ChiSq	P value	Simulated p value	Global p
1,4,6,5,2,11,8,P
	1	CAGCGIGD	0.531	0.511	0.326	0.5683	1	0.01
	2	TTTCGDTD	0.103	0.145	3.336	0.0678	0.465
	3	CTGCAIGD	0.112	0.124	0.247	0.6193	1
	4	CAGCGIGI	0.108	0.064	4.676	0.0306	0.239
	5	CAGTGIGD	0.072	0.046	2.389	0.1222	0.693
	6	TTGCGDGD	0.031	0.067	5.873	0.0154	0.131
	7	CTGCGIGD	0.026	0.024	0.014	0.9057	1
1,4,11,P
	1	CAID	0.622	0.565	3.197	0.0738	0.3053	0.01
	2	TTDD	0.138	0.209	9.084	0.0026	0.0094
	3	CTID	0.143	0.151	0.134	0.714	0.9995
	4	CAII	0.088	0.059	2.735	0.098	0.3809
1,4,11
	1	CAI	0.71	0.625	7.96	0.0048	0.02	0.01
	2	TTD	0.138	0.209	9.085	0.0026	0.011
	3	CTI	0.145	0.152	0.091	0.763	1

Haplotypes observed at over 1% frequency for all 8 variants, the 4 variants typed in additional individuals, and the three variants that showed an association with T2DM. Simulated p values are based on 10,000 simulations in HaploView 3.2; global p values are based on simulations conducted in Phase 2.1.1.