TABLE 1.

Efficacies of Q-D and vancomycin against a glycopeptide-intermediate S. epidermidis strain causing graft infection in a rat model

Groupa	Graft-bonded drug (concn [μg/ml])b	Quantitative graft culture result (CFU/ml)
1		<10
2		5.1 × 106 ± 8.8 × 105
3	Q-Dc,d (100)	<10
4	Q-Dc (10)	2.2 × 102 ± 1.3 × 102
5	(100) Vancomycinc	5.6 × 102 ± 0.3 × 102
6	(10) Vancomycin	2.2 × 106 ± 1.9 × 105

^aEach group consisted of 20 animals; groups 2 to 6 received saline solution (1 ml) containing the VISE strain at a concentration of 2 × 10⁷ CFU/ml

^bThe Dacron graft segments were impregnated with 100 μg of Q-D per ml (group 3), 10 μg of Q-D per ml (group 4), 100 μg of vancomycin per ml (group 5), and 10 μg of vancomycin per ml (group 6). Groups 1 (uncontaminated control) and 2 (untreated control) received nonimpregnated Dacron grafts.

^cStatistically significant compared with group 2.

^dStatistically significant compared with groups 4 to 6.