Figure 2. The Multi-Hit Pathogenesis Model of IgA Nephropathy.
This figure was independently created by synthesizing KDIGO’s conceptual framework [3] with findings from multiple recent mechanistic publications.
BAFF = B-cell-activating factor, APRIL = A proliferation-inducing ligand, IgG = Immunoglobulin G, IgA = Immunoglobulin A, Gd-IgA1 = Galactose-deficient immunoglobulin A 1
