TABLE 1.
Inhibitory effects of different combinations of SLS and LS concentrations on the infectivity of HSV-2 strain 333 on Vero cells after a 1-h pretreatment period at 37°C
| Compound(s) | Mean ED50 ± SD (μM)a | FICSLS + FICLSb | Inhibitory effect |
|---|---|---|---|
| SLS alone | 32.67 ± 2.18 | ||
| SLS + 12.50 μM LS | 10.34 ± 1.77 | 0.40 | Synergistic |
| SLS + 13.75 μM LS | 9.54 ± 1.42 | 0.39 | Synergistic |
| SLS + 15.00 μM LS | 3.12 ± 0.41 | 0.21 | Synergistic |
| SLS + 20.00 μM LS | 3.55 ± 0.28 | 0.25 | Synergistic |
| SLS + 25.00 μM LS | 3.50 ± 0.10 | 0.28 | Synergistic |
| SLS + 50.00 μM LS | 4.23 ± 0.25 | 0.48 | Synergistic |
| LS alone | 141.76 ± 4.10 | ||
| LS + 12.50 μM SLS | 3.32 ± 0.68 | 0.40 | Synergistic |
| LS + 20.00 μM SLS | 3.46 ± 0.70 | 0.75 | Subsynergistic |
| LS + 25.00 μM SLS | 2.73 ± 0.21 | 0.79 | Subsynergistic |
a
Results based on three independent experiments.
b
FICSLS and FICLS are FICs of SLS and LS, respectively.