Table 1.
Frequency of Common GJB2 Recessive Mutations in Different NSHL Population Groups
|
No. (%) of GJB2-Mutation Alleles Screeneda |
||||||
| PopulationEthnicity | Total No. of NSHL Alleles Screened | 35delG | 167delT | 235delC | M34T | Reference(s) |
| Spanish and Italian | 1,546b | 533 (34.48) | 11 (.71) | ND | 1 (.07) | Zelante et al. (1997); Estivill et al. (1998); Murgia et al. (1999); Rabionet et al. (2000b) |
| United Kingdom | 142b | 21 (14.79) | ND | ND | ND | Denoyelle et al. (1997); Lench et al. (1998) |
| United States | 116c | 33 (28.45) | 9 (7.76) | ND | 2 (1.72) | Kelley et al. (1998) |
| Japanese | 308b | ND | ND | 24 (7.80) | ND | Fuse et al. (1999); Abe et al. (2000); Kudo et al. (2000) |
| Ashkenazi Jewish | 60c | 13 (21.67) | 34 (56.67) | ND | ND | Morell et al. (1998); Lerer et al. (2000) |
| French | 204b | 78 (38.24) | ND | ND | ND | Denoyelle et al. (1997); (1999) |
a
ND = not detected.
b
Sib-pair cases and sporadic cases of prelingual NSHL.
c
Autosomal recessive prelingual cases of NSHL.