Table 1.

Results Significant at P<.01, from Initial Screen of Two-Point and Three-Point Conventional and Model-Free Linkage Analyses

Marker at or nearPeak LOD Score	Map Position (cM)	CytogeneticLocation	Most Significant Result Obtained	Nominal P	Comments on LOD Scores
D1S196	186.4	1q22.1-23	Core, recessive, three-point HLOD=2.9	.0006	Nearby markers also positive
D2S125	267.0	2q23.3-24.2	Spectrum, two-point MLOD=1.8	.004	Dominant HLODs positive
D3S1263	29.0	3p24.2-22	Spectrum, two-point MALOD=1.8	.008
D3S1276	109.0	3p14.2-14.1	Core, three-point MLOD=2.5	.0007	Dominant and recessive HLODs positive
D3S1262	107.2	3q27	Spectrum, three-point MFLOD=1.3	.007	Dominant HLODs positive
D4S418	43.9	4q13-31	Spectrum, three-point MFLOD=1.5	.004	Dominant and recessive HLODs positive
D4S430	125.1	4q13-31	Spectrum, two-point MFLOD=2.4	.0004	Dominant and recessive HLODs positive, nearby markers positive
D5S407	65.0	5p14.1-13.1	Spectrum, dominant, two-point HLOD=2.5	.002
D5S422	163.9	5q32-33	Spectrum, dominant, three-point HLOD=3.6	.0001	Nearby markers positive
D7S691	64.6	7p13	Core MLOD=1.4	.01
D8S503	16.2	8p22	Core, recessive, two-point HLOD=3.6	.0001	8p markers positive over wide region
D8S503, D8S504	16.2	8p22	Core, three-point HLOD=3.5	.0001	Recessive HLODs strongly positive, dominant ones less so
D11S922	3.9	11p11.5	Spectrum, three-point MLOD=1.6	.007	Recessive HLODs positive
D11S934	132.9	11q23.3-24	Spectrum, recessive, two-point HLOD=3.1	.0004	Nearby markers positive
D12S43	81.5	12q12-24.1	Core, three-point MALOD=2.0	.005	Dominant HLODs positive
D19S220	61.4	19q13.1	Spectrum, two-point MLOD=1.5	.009
D20S112	39.3	20q12.1-11.23	Spectrum, recessive, three-point HLOD=2.4	.002	Nearby markers positive
D21S1256	8.7	21q11.1-21.1	Spectrum, two-point MALOD=1.9	.006	Dominant and recessive HLODs positive