Table 10.
Results of χ2 Tests for Association between SNPs in Nine Genes and RA, and Estimation of Relationships between Eight SNPs and rIL-3-16
|
LOD Scoreb |
||||
| Gene Containing SNP | Association Test of 91 Cases of RA vs. 91 Controls (χ2a [P]) | Combinatorial Pattern | Independent Pattern | Difference |
| MMP2 | 1.93 [.16] | 1.7 | 1.8 | −.1 |
| TNFR1 | 1.99 [.16] | 1.9 | 1.6 | .3 |
| STAT6 | 2.23 [.14] | 1.6 | 1.7 | −.1 |
| IL−15 | 2.58 [.11] | 1.7 | 1.8 | −.1 |
| IL-1β | 2.91 [.09] | 2.8 | 2.0 | .8 |
| CD44 | 3.92 [.05] | 3.4 | 2.8 | .6 |
| IL-4Rα | 4.85 [.03] | 2.4 | 2.4 | .0 |
| TIMP1 | 5.30 [.02] | 3.3 | 3.4 | -.1 |
| IL-3 (rIL-3-16) | 5.67 [.02] | … | … | … |
a
Maximum value, among comparisons of genotype frequencies.
b
Under hypothesis that no association exists between two SNPs and RA.