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Effect of voriconazole on tacrolimus metabolism. Tacrolimus (50 ng/ml) was incubated in the presence of various concentrations of voriconazole (0 to 100 μg/ml). The amount of tacrolimus metabolized per time in the absence and in the presence of various concentrations of voriconazole was measured by MEIA. At a concentration of 6.3 μg/ml, voriconazole inhibits the metabolism of tacrolimus by 50% in one microsome sample.
