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Comparison of metabolic stability of VRC4232 and VRC4307, as determined in vitro by incubation with liver microsomes from mice, rats, and humans
| Compound |
t1/2 (min) in:
|
Clearance (μl/min/mg) in:
|
||||
|---|---|---|---|---|---|---|
| Mice | Rats | Humans | Mice | Rats | Humans | |
| VRC4232 | 3.1 | 2.6 | 26.8 | 1,100 | 1,309 | 129 |
| VRC4307 | 2.2 | 2.0 | 19.9 | 1,594 | 1,700 | 174 |
