TABLE 4.
Strain | MIC (μg/ml)
|
Detected mutation(s) | ||||
---|---|---|---|---|---|---|
ERY | AZM | CLR | CLI | Q-D | ||
Parent 3 | 8 | 2 | 4 | 32 | 2 | |
C3b | 64 | 8 | 64 | 256 | 8 | G65D |
Parent 5 | 4 | 2 | 8 | 16 | 2 | |
C5 | 32 | >128 | 32 | 32 | 32 | Delc 65GR |
Parent 10 | 16 | 4 | 16 | 16 | 4 | |
C10 | 128 | 16 | 128 | 4 | 8 | G53A, Del 66RA |
Abbreviations: ERY, erythromycin; AZM, azithromycin; CLR, clarithromycin; CLI, clindamycin; Q-D, quinupristin-dalfopristin.
Mutant strain designations are formed by the first letter of the antibiotic (A for AZM and C for CLR) and the number of parent strain used for selection.
Del, deletion.