TABLE 2.
Parameter (unit)b | Result fora:
|
Pc | |
---|---|---|---|
Liposomal amphoter-icin B (2 mg/kg) | Amphotericin B deoxy-cholate (0.6 mg/kg) | ||
Cmax (μg/ml) | 22.9 ± 10 | 1.43 ± 0.2 | <0.01 |
C24h (μg/ml) | 1.9 ± 1.8 | 0.25 ± 0.03 | NS |
AUC0-24 (μgh ml−1) | 171 ± 126 | 13.9 ± 2.0 | NS |
AUC0-∞ (μgh ml−1) | 288 ± 209 | 46.6 ± 7.2 | NS |
t1/2α (h) | 0.56 ± 0.48 | 0.17 ± 0.14 | NS |
t1/2β (h) | 6.0 ± 2.1 | 6.8 ± 1.6 | NS |
t1/2γ (h) | 152 ± 116 | 127 ± 30 | NS |
V1 (ml/kg) | 50.1 ± 19 | 136 ± 60 | <0.05 |
V (ml/kg) | 1,628 ± 876 | 2,340 ± 202 | NS |
Vss (ml/kg) | 774 ± 550 | 1,807 ± 239 | <0.01 |
CL (ml h−1 kg−1) | 9.7 ± 5.4 | 13.1 ± 2.0 | NS |
CLR (ml h−1 kg−1) | 0.495 ± 0.25 | 4.1 ± 0.68 | <0.01 |
CLF (ml h−1 kg−1) | 0.488 ± 0.46 | 5.4 ± 0.91d | <0.01 |
Furine | 0.053 ± 0.006 | 0.32 ± 0.06 | <0.01 |
Ffeces | 0.047 ± 0.04 | 0.43 ± 0.11d | <0.01 |
Values are means ± standard deviations (n = 5 subjects per treatment).
C24h, concentration of drug in plasma at 24 h.
NS, not significant (P > 0.05).
n = 4 (incomplete fecal collection in one subject).