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Intracellular concentrations of doxorubicin in parental MCF-7 cells and drug-selected sublines as determined by laser cytometry
| Drug | Concn (μM) of doxorubicin in cell linea:
|
||
|---|---|---|---|
| MCF-7 | MCF-7/Adr | MCF-7/doxy | |
| Doxorubicin | 700∗ (7.7) | 329‡ (5.8) | 221§ (5.9) |
| Doxorubicin + verapamil | 770† (5.6) | 770† (5.1) | 756† (7.1) |
Values are expressed as means (standard errors). Values identified with different symbols are significantly different (P < 0.05).
