TABLE 1.
Relationships between animals with culture-positive ME samples and frequencies of otorrhea, volumes of MEWF recovered, and variations in body weight in an experimental model of otitis media caused by S. pneumoniaea
| Group and antibiotic dose (mg/kg) | No. (%) of animals with culture-positive ME samples
|
Frequency of otorrhea (%) | MEWF vol (μl) (mean ± SD) | Body wt loss (%) (mean ± SD) | ||
|---|---|---|---|---|---|---|
| Bilateral | Unilateral | Total | ||||
| Untreated controls | 10 (100) | 0 (0) | 10 (100) | 100 | 20.3 ± 7.7 | 10.4 ± 1.7 |
| Amoxicillin-treated animals | ||||||
| 0.2 | 6 (60) | 3 (30) | 9 (90) | 85 | 24.4 ± 8.6 | 9.3 ± 2.7 |
| 0.4 | 5 (50) | 2 (20) | 7 (70) | 80 | 25.5 ± 7.2 | 7.6 ± 3.8 |
| 0.8 | 4 (40) | 2 (20) | 6 (60) | 80 | 26.0 ± 9.1 | 7.4 ± 3.8 |
| 1.25 | 2 (20) | 1 (10) | 3 (30) | 40b | 22.7 ± 9.5 | 3.9 ± 2.7b |
| 2.5 | 0 (0) | 1 (10) | 1 (10) | 10b | 24.9 ± 8.9 | 1.8 ± 2.6b |
| 5.0 | 0 (0) | 0 (0) | 0 (0) | 10b | 30.9 ± 11.1b | 2.1 ± 2.7b |
a
Data at day 2, except those for frequency of otorrhea (day 1).
b
Significantly different (P ≤ 0.05) compared with value for control group.