TABLE 1.
Drug | Degree of correlation (r2) of indicated drug
|
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rit | Nel | Saq | Amp | ABC | 3TC | AZT | d4T | ddC | ddI | EFV | Nev | Del | |
PIs | |||||||||||||
Ind | 0.79 | 0.70 | 0.69 | 0.55 | 0.24 | 0.14 | 0.26 | 0.11 | 0.10 | 0.15 | 0.11 | 0.14 | 0.09 |
Rit | 0.69 | 0.67 | 0.58 | 0.25 | 0.15 | 0.27 | 0.11 | 0.09 | 0.15 | 0.10 | 0.13 | 0.08 | |
Nel | 0.63 | 0.45 | 0.25 | 0.18 | 0.26 | 0.10 | 0.10 | 0.14 | 0.10 | 0.13 | 0.08 | ||
Saq | 0.49 | 0.21 | 0.10 | 0.24 | 0.11 | 0.08 | 0.14 | 0.10 | 0.12 | 0.08 | |||
Amp | 0.21 | 0.08 | 0.22 | 0.12 | 0.10 | 0.15 | 0.08 | 0.09 | 0.06 | ||||
NRTIs | |||||||||||||
ABC | 0.42 | 0.35 | 0.24 | 0.36 | 0.38 | 0.08 | 0.10 | 0.04 | |||||
3TC | 0.09 | 0.03 | 0.25 | 0.21 | 0.04 | 0.06 | 0.02 | ||||||
AZT | 0.29 | 0.14 | 0.19 | 0.06 | 0.08 | 0.03 | |||||||
d4T | 0.19 | 0.23 | 0.03 | 0.03 | 0.02 | ||||||||
ddC | 0.33 | 0.02 | 0.03 | 0.01 | |||||||||
ddI | 0.06 | 0.07 | 0.05 | ||||||||||
NNRTIs | |||||||||||||
EFV | 0.70 | 0.62 | |||||||||||
Nev | 0.68 | ||||||||||||
Del |
The degree of correlation in fold change in 50% inhibitory concentration compared to that of a reference strain (log scale) among over 4,900 clinically derived recombinant isolates is expressed as r2. Even with low values of r2, most correlations are highly statistically significant due to the large number of observations. Ind, indinavir; Rit, ritonavir; Nel, nelfinavir; Saq, saquinavir; Amp, amprenavir; ABC, abacavir; 3TC, lamivudine; AZT, zidovudine; d4T, stavudine; ddC, zalcitabine; ddI, didanosine; EFV, efavirenz; Nev, nevirapine; Del, delavirdine.