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. 2002 Mar;46(3):909–912. doi: 10.1128/AAC.46.3.909-912.2002

TABLE 1.

Correlations among antiretroviral susceptibilitiesa

Drug Degree of correlation (r2) of indicated drug
Rit Nel Saq Amp ABC 3TC AZT d4T ddC ddI EFV Nev Del
PIs
    Ind 0.79 0.70 0.69 0.55 0.24 0.14 0.26 0.11 0.10 0.15 0.11 0.14 0.09
    Rit 0.69 0.67 0.58 0.25 0.15 0.27 0.11 0.09 0.15 0.10 0.13 0.08
    Nel 0.63 0.45 0.25 0.18 0.26 0.10 0.10 0.14 0.10 0.13 0.08
    Saq 0.49 0.21 0.10 0.24 0.11 0.08 0.14 0.10 0.12 0.08
    Amp 0.21 0.08 0.22 0.12 0.10 0.15 0.08 0.09 0.06
NRTIs
    ABC 0.42 0.35 0.24 0.36 0.38 0.08 0.10 0.04
    3TC 0.09 0.03 0.25 0.21 0.04 0.06 0.02
    AZT 0.29 0.14 0.19 0.06 0.08 0.03
    d4T 0.19 0.23 0.03 0.03 0.02
    ddC 0.33 0.02 0.03 0.01
    ddI 0.06 0.07 0.05
NNRTIs
    EFV 0.70 0.62
    Nev 0.68
    Del
a

The degree of correlation in fold change in 50% inhibitory concentration compared to that of a reference strain (log scale) among over 4,900 clinically derived recombinant isolates is expressed as r2. Even with low values of r2, most correlations are highly statistically significant due to the large number of observations. Ind, indinavir; Rit, ritonavir; Nel, nelfinavir; Saq, saquinavir; Amp, amprenavir; ABC, abacavir; 3TC, lamivudine; AZT, zidovudine; d4T, stavudine; ddC, zalcitabine; ddI, didanosine; EFV, efavirenz; Nev, nevirapine; Del, delavirdine.