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. 2025 Sep 30;70(Suppl 1):S129–S145. doi: 10.1111/adj.70007

Static‐Computer Assisted Implant Surgery: Where Are We Now?

Xin Hui Yeo 1, Shengchi Fan 1,2,3, Jennifer G M Chantler 4,5, James Chow 6, Atiphan Pimkhaokham 1, Nikos Mattheos 1,7,8,
PMCID: PMC12747637  PMID: 41028940

ABSTRACT

Background

Static Computer‐Assisted Implant Surgery (s‐CAIS) has become a widely accepted standard in guided implant placement, leveraging advancements in digital technologies. Despite its widespread adoption, s‐CAIS faces several limitations, and emerging alternatives like dynamic and robotic CAIS are gaining traction.

Methods

This narrative review synthesises the current literature on s‐CAIS to provide a comprehensive overview of its current state, clinical applications, and future potentials. Key aspects included s‐CAIS terminology and componentry, indications, clinical outcomes, patient‐reported experience, educational implications, advantages, and limitations.

Results

s‐CAIS demonstrates superior accuracy compared to non‐guided surgery. It can enhance efficiency in complex cases and facilitate minimally invasive and immediate loading protocols. However, limitations include restricted intraoperative flexibility, higher costs, and challenges in cases with limited access or unusual anatomy.

Conclusion

Despite emerging technologies such as dynamic navigation and robotic assistance, s‐CAIS remains a predictable and widely used modality for guided implant placement. Clinicians should weigh its advantages against limitations and consider patient‐specific factors when selecting guided surgery approaches. Further research should prioritise collective assessment of clinical and patient‐reported outcomes over accuracy metrics alone.

Keywords: dental implants, digital workflow, static guided surgery, static‐computer assisted implant surgery (s‐CAIS), surgical guide


Summary.

  • s‐CAIS is at present an affordable, accessible and predictable technology to assist accurate implant placement.

  • Rather than a single technology, s‐CAIS is an entire workflow encompassing multiple steps and several interconnected devices.

  • s‐CAIS can benefit the patients by increasing efficiency and reducing the invasiveness of implant procedures.

  • Understanding not only the workflow but also its indications, potentials and limitations is imperative in modern implant practice.

  • While advancements with dynamic and robotic CAIS may decrease the overall reliance on surgical guides, it is anticipated that s‐CAIS will continue to serve as the primary modality of guided implant placement in the near future.

1. Introduction

Prosthetically driven implant planning, combined with precise execution of Computer Assisted Implant Surgery (CAIS), has become the gold standard in dental implant rehabilitation [1]. Clinical evidence indicates that the factors of implant malposition [2, 3] and suboptimal prosthesis design [4] significantly compromise peri‐implant health and long‐term success. With the advent of digital innovations, prosthetic components can now be virtually designed according to established biological and mechanical principles. Consequently, achieving optimal clinical outcomes relies critically on the accurate translation of virtual planning into surgical reality.

Since the inception of computer‐aided planning and surgery in the late 90s [5, 6], static‐CAIS (s‐CAIS) has morphed into a predictable, clinically accessible and well‐documented surgical modality with over more than two decades of application. Numerous studies have reported their potential for enhancing the accuracy of implant placement [7], although certain limitations or challenges persist.

Meanwhile, new technological paradigms such as dynamic CAIS (d‐CAIS) and robotic CAIS (r‐CAIS) are rapidly emerging. These modalities offer enhanced intraoperative visualisation and surgical flexibility, yet they demand higher technical proficiency and come with increased costs. As the field continues to evolve, clinicians are faced with a critical decision point regarding the most appropriate CAIS modality for routine practice. Hence, a comprehensive overview of s‐CAIS is essential to support clinical decision‐making and promote evidence‐based practice.

The aim of this narrative review is to summarise the current state of the science and art in s‐CAIS and to clarify its role in contemporary clinical practice by focusing on the following aspects: (a) terminology and componentry, (b) indications, (c) clinical outcomes, (d) patient‐reported outcomes, (e) implications for education and training, (f) advantages and limitations, and (g) future directions and potentials.

1.1. S‐CAIS Terminology and Componentry

In the context of implant dentistry, a surgical guide is defined by the Glossary of Computer‐Assisted Implant Surgery and Related Terms [1] as “CAD/CAM device aiming to guide the osteotomy and the placement of a dental implant in the planned position or be used to guide other modifications of the anatomy, such as ostectomy, gingivectomy, sinus surgery, etc. This device is used temporarily in the patient's oral cavity during surgery with or without fixation elements.” Although surgical guide has historically been historically the focus of attention, the s‐CAIS workflow extends beyond surgical guides and requires a wider purpose‐made set‐up (Table 1), described as a Guided Implant Surgery System (GISS), which includes a variety of components to be utilised under an often‐proprietary Guided Implant Surgery Protocol (GISP). Key to the entire workflow is the digital treatment plan, which requires a sound understanding of implant dentistry and a specifically designed Computer‐Aided Design Implant Planning software (CAD‐IPS) [1].

TABLE 1.

Different elements of an s‐CAIS workflow, including characteristics of the surgical guide.

Aspect of s‐CAIS Details
Extent of guidance
  • Fully guided

  • Partially guided (including pilot drill guide)

Drill bit design
  • Sleeve‐in‐sleeve

  • Mounted sleeve‐on‐drill

  • Integrated sleeve‐on‐drill

Sleeves Material
  • Stainless steel

  • Titanium

  • Zirconia

  • PEEK

Design
  • Open

  • Closed

Features
  • Self‐locking

  • Non‐locking

Surgical guide Support
  • Teeth‐supported

  • Mucosa‐supported

  • Bone‐supported

  • Implant‐supported

  • Hybrid

Extent
  • Full coverage

  • Partial coverage

Stabilisation/retention
  • Fixation pins

  • Ball clasps

Multiple‐guides
  • Stackable guides

  • Interchangeable guides

Material
  • Acrylic

  • Resin

  • Metal (Stainless steel/titanium)

Manufacturing
  • Additive (3D printing)

  • Subtractive (Milling)

CAD Implant Planning Software (CAD‐IPS) Access
  • Open platform

  • Closed system

Most documented brands
  • CoDiagnostix

  • Nobel Clinician

  • Bluesky Bio

  • DTX Implant Studio

  • Exocad

  • Romexis

  • 3D StendCad

  • 6D Planning

  • Simplant

  • 3Diagnosys

  • R2Gate

  • OnDemand 3D

  • RealGuide

  • SMOP

  • SmilePlan

  • Galimplant

  • Implant Viewer

Although most commercially available GISS abide by the same fundamental principles for guiding the osteotomy and implant placement, there is a wide variety of surgical guide and instrument designs, as well as corresponding protocols. It is important to note that this diversity in hardware, software, and protocols is rather attributed to different design philosophies among manufacturers, rather than comparative research [8]. Currently available GISS can be categorised in many ways, depending on the components and workflow in focus. From the point of clinical relevance, it might be most interesting to focus on the different (a) Surgical guide designs and (b) Guided implant surgery kits (GISK).

1.1.1. Surgical Guide Designs

Surgical guides have historically been used in many ways, from guiding only the pilot drill (pilot‐guided) to guiding the entire osteotomy (partially‐guided) and guiding both osteotomy and implant placement (fully‐guided). The fully guided approach has been shown to offer superior outcomes in terms of accuracy [9, 10, 11, 12, 13, 14, 15, 16]. Although it is well anticipated that all major design elements can contribute to clinical outcomes or predispose to complications and deviation, there is very little evidence comparing different surgical guide design elements and principles. Surgical guides can be organised based on the support mechanism:

  • Tooth‐supported (Figure 1a);

  • Mucosa‐supported (Figure 1b);

  • Bone‐supported (Figure 1c);

  • Implant‐supported

  • Hybrid (a combination of the above)

FIGURE 1.

FIGURE 1

(a–e) Different types of surgical guides organised on the basis of support.

Tooth‐ and mucosa‐supported surgical guides allow flapless or minimally invasive flap elevation procedures, whereas bone‐supported guides typically require full‐thickness flap elevation. Anchor or fixation pins can be used to ensure retention and stability, often arranged in a tripod configuration on the buccal or palatal, or a combination of both surfaces. In more complex cases where multiple guides are needed, the system may be stackable (Figure 1d) or interchangeable (Figure 1e). Stackable guides typically involve a base guide that is secured to the bone with fixation or anchor pins, upon which subsequent guides are placed using mechanical interlocking, pins, or magnets. Interchangeable guides rely on an initial guide to establish pin channels; once these are placed, the initial guide is removed and replaced with a subsequent guide that fits securely into the pre‐established pin positions.

Osteotomy surgical guides commonly incorporate sleeves to enhance drill guidance. The sleeves are inserted into the guide and stabilised either by friction fit or bonding. Regardless of the stabilisation method, it is essential to ensure that the sleeve remains secure throughout the surgical procedures (Figure 2). Sleeveless guides are also frequently used; however, some manufacturers have raised concerns about the potential generation of guide material debris contaminating the osteotomy site, caused by friction between the drill bit and the guide. The position of the sleeve should have sufficient clearance from the soft tissue or bone, and this is taken into consideration during the planning stage based on the CBCT and intraoral scan. The guide sleeve is available in various standard diameters and can be made of different materials, commonly titanium, steel, or Polyetheretherketone (PEEK), the latter of which could have locking or non‐locking features.

FIGURE 2.

FIGURE 2

Example of incomplete seating of sleeve in surgical guide being used to guide implant osteotomy.

A unique design feature for a tooth‐supported surgical guide is the incorporation of inspection windows, which allow clinical verification of full seating of the guide. It is recommended that these windows are positioned bilaterally to the implant site for optimal visual confirmation [17].

The surgical guide can then be additionally described based on the material it is made of, typically resin or acrylic and metal.

Surgical guides are not to be confused with intraoperative prosthetic templates (Figure 3), which are vacuum‐formed stents manufactured on a replacement tooth digital or analogue wax‐up to provide the proposed position of the final prosthesis as a reference to the surgeon. The continued use of such templates is based on operator preference; however, they do not, however, belong to the guided‐CAIS workflow.

FIGURE 3.

FIGURE 3

Examples of intraoperative template (non‐guided‐CAIS): (a) Mucosa‐supported partially guided stent. (b) Example of tooth‐supported pilot‐guided surgical stent.

1.1.2. Guided Implant Surgery Kits (GISK)

These kits consist of proprietary‐designed instruments such as drill bits, which interact with the surgical guide through a variety of interfaces. These instruments are essential for controlling the three‐dimensional position of the osteotomy. Common drill‐guide interfaces include sleeve‐in‐sleeve (with an additional handheld drill key or handle), integrated sleeve‐on‐drill designs, and mounted sleeve‐on‐drill systems with or without a sleeve in the surgical guide (Figure 4) [8].

FIGURE 4.

FIGURE 4

Designs of drills for different Guided Implant Surgery Systems (GISS) (Figure courtesy of Atiphan Pimkhaokham): (a) Sleeve‐in‐sleeve, non‐interlocking, (b) sleeve‐in‐sleeve, interlocking, (c) mounted sleeve‐on‐drill, (d) integrated sleeve‐on‐drill, (e) integrated sleeve‐on‐drill, sleeveless surgical guide.

Clinicians often report the sleeve‐in‐sleeve design as the most ergonomically challenging. It requires the surgeon to hold an additional component during the osteotomy, unless a self‐locking sleeve is used. These systems are typically developed by implant manufacturers to support implant placement of their specific production line. Assessment of GISK should consider not only accuracy, but also ergonomics and cost‐effectiveness, to provide clinically relevant insights and support informed decision‐making. Too often, the guide system is selected as a by‐product of implant choice, potentially limiting the clinicians' autonomy and efficiency.

1.2. Indications

Although surgical guides were initially developed for the accurate placement of dental implants, the concept gradually expanded to include other indications, either related to implant surgery (e.g., pre‐implant mandibular ostectomy) or non‐implant‐related procedures (e.g., crown lengthening surgery). Currently, the most common indications for the use of surgical guides as adjuncts to implant surgery include (a) bone reduction/ostectomy, (b) window osteotomy for lateral maxillary sinus floor elevation (MSFE), (c) immediate implant placement with the partial extraction/socket shield technique, and (d) zygomatic and pterygoid implant placement.

1.2.1. Bone Reduction/Ostectomy

Surgical guide can be designed to guide the amount of bone reduction to the planned level of implant platform (Figure 5). This is applicable in immediate implant cases with uneven bone levels around teeth with poor prognosis, or in fully edentulous patients presented with knife‐shaped alveolar ridge (Cawood and Hawell class IV) [18]. Currently there is little evidence with regard to the accuracy of bone reduction and its significance in relation to the final implant positioning [19]. Only one study with a small sample size of 4 patients reported a mean discrepancy in volume, level and angular deviation between virtual ostectomy and actual ostectomy of 493 mm3, 0.0248 mm and 6.03° respectively [20].

FIGURE 5.

FIGURE 5

Bone reduction guide (photo courtesy of Dr. Jarungvit Lorwicheanrung).

1.2.2. Lateral Maxillary Sinus Floor Elevation (MSFE)

In guided MSFE (Figure 6), the use of a surgical stent to transfer the outlines of the planned lateral window osteotomy can improve accuracy, reduce the time required, and possibly contribute to a reduction of morbidity by avoiding anatomical landmarks such as septa and vessels [21, 22, 23]. However, a recent clinical trial showed that patients operated on with s‐CAIS surgical guides in MSFE reported significantly more swelling than those who underwent free‐hand surgery. This prompted the authors to reflect and emphasise on the importance of guide design and to recommend the reduction of the size of the upper part of the frame, which corresponds to the superior border of the lateral window [23]. The surgical guide could also be designed to accommodate a hydraulic pressure device for the crestal sinus lift approach as part of the implant drill sequence (e.g., Crestal Approach Sinus/CAS kit).

FIGURE 6.

FIGURE 6

(a–c): Sinus lift surgical guide, (a, b) physical guide, (c) digital plan (photos courtesy of Dr. Peiman Yazdani).

1.2.3. Partial Extraction/Socket Shield Technique

The socket shield technique, which aims to preserve the labial bone in immediate implant cases, is a highly technique‐sensitive protocol requiring training and skills. Several case reports have described the use of a surgical guide to guide root separation prior to guided implant placement [24, 25]. However, no further comparative data are available on clinical outcomes of guided root shield preparation technique versus freehand.

1.2.4. Zygomatic/Pterygoid Implants

Zygomatic and pterygoid implants are considered viable alternatives for the rehabilitation of the severely atrophic maxilla, offering the advantage of avoiding extensive bone grafting procedures, reducing patient morbidity, and shortening overall treatment time. However, their placement is technically demanding due to the long drilling trajectory and the proximity of critical anatomical structures such as the orbital floor and the infratemporal fossa. Compared to s‐CAIS in conventional dental implantology, the application of surgical guides for zygomatic implant placement has been reported far less frequently in the literature [26, 27, 28, 29, 30, 31, 32]. Chrcanovic et al. noted that conventional surgical templates were insufficient for achieving accurate zygomatic implant placement [29], largely due to the challenges posed by the extra‐long implant length, which led to instability of the drill at the apical endpoint. An additional difficulty is in achieving proper stabilisation of the surgical guide on a severely resorbed, edentulous maxilla.

To address these limitations, modified s‐CAIS systems for zygomatic implant placement such as incorporating double sleeve designs and reinforced materials at the entry point and zygomatic emergence zone, have been suggested to improve accuracy [28, 33, 34, 35, 36]. A recent systematic review concluded that the use of double‐sleeve guide in zygomatic implant surgery produces clinically acceptable outcomes in terms of mean deviations [37]. Nevertheless, despite reporting favourable means, substantial maximum deviations were also reported. Thus, clinicians must remain vigilant for potential inaccuracies and complications, regardless of the guiding modality employed.

1.3. Clinical Outcomes

1.3.1. Accuracy (Trueness and Precision)

The accuracy of implant placement is the most extensively investigated parameter in s‐CAIS, serving as the central focus of a substantial body of both clinical and preclinical research aimed at validating its reliability [7].

Accuracy is typically quantified as the deviation between the planned and actual three‐dimensional (3D) implant position, specifically at the platform, apex, and angulation [38]. Historically, the term “accuracy” has often been used interchangeably with “trueness”. However, as directed by the latest directive of the International Standardisation Organisation (ISO 5725) [39], both trueness (the closeness of agreement between the planned implant position and the achieved implant position) and precision (the closeness of agreement between repeated implant placement under the same conditions) would be required to define accuracy. Thus, the majority of published clinical and simulation research should be interpreted as assessment of trueness alone. Little is known with regard to precision as only a few studies truly assessed and reported on precision [40, 41, 42, 43] in simulation studies.

A large body of clinical studies, also analysed collectively at several meta‐analyses [44, 45, 46, 47], has confirmed beyond doubt the ability of s‐CAIS to deliver superior trueness of implant placement than non‐guided surgery. At least with regards to the average deviation, the outcomes of s‐CAIS are comparable to what is achieved using d‐CAIS. A recent meta‐analysis [48] employed K‐means clustering to analyse the deviation outcomes from comparative clinical trials evaluating guided versus non‐guided implant placement. The analysis identified three primary clusters based on deviation patterns:

  • Low deviation (< 0.67 mm platform, < 2.2° angle), which was the outcome of robotic or hybrid CAIS,

  • Medium Deviation (0.67–1.30 mm platform, 2.2°–5.1° angle) which was dominated by implants placed under s‐ or d‐CAIS, and

  • High Deviation (> 1.30 mm platform, > 5.1° angle) which was the outcome of non‐guided controls.

Thus, based on the current literature, the best available benchmark for s‐CAIS trueness is the range presented in the medium deviation group. However, accuracy metrics presented as stand‐alone numerical values often lack clinical interpretability, as they obscure critical spatial patterns essential for troubleshooting and workflow optimisation. For example, some authors have documented systemic deviation towards a specific direction (e.g., mesial‐distal or buccal‐lingual) or a clustering effect when implants were placed using a surgical guide [49, 50, 51], which they attributed to the influence of systemic errors in planning or execution such as habitual operator factors or ergonomics, surgical site access, guide misalignment, and the built‐in tolerance of the GISS. These directional trends are “invisible” in analyses focused on average trueness but reveal important limitations of s‐CAIS technology, especially under real‐life clinical conditions. Furthermore, when the deviation was analysed as a distribution curve [52], it was shown that implants placed with d‐CAIS appear to be more frequently within a favourable deviation margin (angular and apical) than those placed with s‐CAIS. Finally, although individual studies have failed to show any difference, meta‐analysed large data have favoured d‐ over s‐CAIS with regard to the achieved angular deviation [53, 54, 55, 56].

It must be noted as well that s‐CAIS is not a singular technology, but rather a multifaceted workflow comprising multiple sequential steps and the integration of various software and hardware components. Each element within this workflow has the potential to influence the final clinical outcome. Several steps and devices of this workflow have been assessed for potential contribution to the final trueness (Figure 7; Tables 2 and 3).

FIGURE 7.

FIGURE 7

CAD‐CAM surgical guide standardised, step‐by‐step protocol.

TABLE 2.

Major steps of the digital workflow in s‐CAIS with potential risk to introduce errors, which could cumulatively contribute to the clinical outcomes, in particular adding up to deviation from the planned implant position.

Stage Potential risk for errors/inaccuracies
CBCT

Scattering induced by metallic restorations

Movement artefacts

Low sensitivity in detecting thin bone

Optical Scan (Intraoral)

Intraoral conditions

Lighting conditions

Scanner displacement

Operator experience

Inability to capture

Mobile soft tissue

Optical Scan (Extraoral) Analogue model distortion of the impression being replicated in the model scan
Digital Implant Treatment Plan (DITP) and Implant Planning Software (CAD‐IPS)

Selection of CAD‐IPS (surgical or restorative functionality)

Data Registration accuracy

Selection of proper planes

Reduced Field of View or insufficient landmarks for data registration

Accuracy of data segmentation, in particular when algorithms are used (Over‐segmentation/under‐segmentation)

Panoramic curve simulation

Guide design

Path of insertion, attention to undercuts

Optimal kind of tissue support selection

Material selection

Material thickness

Anchorage elements design and location

Guide fabrication and storage

Printing/milling errors/discrepancies

Deficient curing of resin

Storage & transport conditions

Dimensional changes or structural deformation

Sleeve insertion, cementation and stability

Guide seating

Misfit/improper fit

Deficient stability

Inadequate tolerance (too tight/too loose)

Interference with soft tissue thickness

Guide use (Intraoperative)

Displacement

Fracture

Inability to insert/withdraw guided drills

Systemic error due to ergonomic access

TABLE 3.

Factors of surgical guide design and drill support which can influence the trueness of the final implant position (or other outcomes, if specifically mentioned) as suggested by simulation and clinical trials.

Factors Accuracy (trueness) level Study types
Surgical guide support

‐ Teeth or implant > Mucosa > Bone [10, 38, 44, 49, 57, 58, 59]

‐ Mucosa = Bone [60]

‐ More teeth ↑ higher trueness [61]

‐ Posterior > Anterior teeth [62]

‐ Two teeth on each side = Full‐arch surgical guide covering seven teeth [63]

‐ 6 teeth > 4 teeth (single immediate placement) [61]

[10, 44, 49, 58] a

[57] b

[38, 60] c

[59] d

[61, 62, 63] e

Guide design/material

Rigid > Flexible [14]

Sufficient thickness [14]

[14] d
Guide fabrication method

Accuracy: Additive = Subtractive [64, 65, 66]; Milling > 3D printing [67, 68]

Cost‐effectiveness: 3D printed > Milled [59]

* 3D printers have different manufacturing accuracy [68, 69, 70]

[67] a

[59] e

[64, 65, 66, 68, 69, 70] d

Size of edentulous space Single tooth gap > Extended edentulous span [57, 62]

[57] b

[62] d

Location of the gap

Bounded saddle > Distal extension [13, 57, 63, 71, 72, 73]

Anterior implant > Posterior [12]

[13, 73] a

[57] b

[12, 71, 72] e

[63] d

Immediacy Healed sites > Fresh extraction sockets [74] [74] e
Flap Flapless > Flap [15, 75, 76] [15, 75, 76] a
Implant design Deep‐threaded tapered > Shallow‐threaded parallel‐walled [77] [77] d
Sleeve

Sleeveless > Metal sleeve (for sleeve‐in‐sleeve system) [77, 78, 79]

Metal sleeve = Sleeveless (for mounted or integrated sleeve‐on‐drill systems) [42, 80]

Sleeveless > Metal sleeve (for mounted sleeve‐on‐drill and sleeve‐in‐sleeve drill systems) [74, 81]

Sleeveless > Metal sleeve (for mounted sleeve‐on‐drill) [82]

[81] a

[82] c

[42, 74, 77, 78, 79, 80] d

Sleeve design Closed sleeve > Open sleeve design > Freehand (in healed sites and immediacy cases) [83, 84]

[83] e

[84] d

Sleeve height Higher sleeve > shorter sleeve [85, 86, 87] [85, 86, 87] d
Drill key design

Keyless > Sleeve‐in‐sleeve [74, 88]

Sleeve‐in‐Sleeve > Keyless [80, 85]

[88] a

[74, 80, 85] d

Drill key length Longer drill key > Short drill key [87, 89] [87, 89] e
Drill length Short drills > Long drills [17, 62, 87]

[17] b

[62, 87] d

Guide offset

Minimum essential guide‐to‐teeth offset: 0.1–0.15 mm [62, 77, 79, 90]

Minimal bone offset or sleeve‐to‐bone distance ↑ higher accuracy [40, 62, 78, 86]

Minimal sleeve‐to‐guide and drill‐to‐sleeve offset/tolerance ↑ stability [86, 87]

[40, 62, 77, 78, 79, 86, 87, 90] d
Guidance Fully guided > Partially guided > Pilot guided [9, 10, 40, 46, 76]

[9, 10, 46, 76] a

[40] e

Other elements

Fixation pins ↑ stability in mucosa‐ and bone‐supported guides [16, 91] and in edentulous cases [67, 92, 93]

More fixation pins ↑ higher trueness [49]

Cross‐arch support bar > No bar (↑rigidity, distortion [94, 95, 96] and ↑stability [97])

One‐piece guide > Stackable guide (cumulative errors) [19]

[49, 67] a

[19] b

[16, 92, 93, 94, 95] e

[91, 96, 97] d

Note: “>” indicating superior outcome, “ = ” indicates comparable outcome, “↑” indicates positive association, “” indicates negative association.

a

Systematic review (in vivo, ex vivo, in vitro).

b

Critical review/scoping review.

c

Randomised Clinical Trial.

d

Simulation study.

e

Clinical Trial.

1.3.2. Time Efficiency and Cost‐Effectiveness

S‐CAIS has been shown to significantly reduce chairside time during complex interventions such as multiple implant placement in fully edentulous patients, particularly when performed using a flapless surgical technique [59, 98]. In partially edentulous patients, the evidence regarding surgical time remains inconsistent. While some studies have reported shorter surgical time with fully guided and pilot guided s‐CAIS compared to non‐guided placement [99, 100], others have demonstrated similar results between the approaches [101, 102]. However, in cases of single gap, non‐guided CAIS or conventional surgery appears consistently faster, especially in simple, straightforward cases [8, 103, 104]. Seating and removal of surgical guide may prolong the duration of the surgery, particularly when intraoperative adjustments are needed to enhance guide fit. Although such modifications are generally infrequent, reported adjustment times vary considerably, ranging 1–17 min [23].

1.3.3. Teeth‐In‐a‐Day (Immediate Loading)

It is not surprising that immediate loading was the indication that introduced the concept of guided implant placement as early as 1999 [6], as accurate placement of the implants is essential to allow immediate restoration with prefabricated prostheses (Figure 8). The time required to fit the temporary prosthesis was found to be significantly shorter when surgical guides were used [99], while patient satisfaction with the overall treatment is shown to be more influenced by the presence of immediate restoration than by the extent of post‐operative discomfort [99, 105], particularly in the aesthetic zone, where patients' expectations are higher.

FIGURE 8.

FIGURE 8

Immediate pick up for full‐arch restoration. Immediate fixed prosthesis enables better control of loading forces and directions on the implants and provides cross‐arch stabilisation for the implants. (Photo courtesy of Dr. Peiman Yazdani).

1.4. Patient Reported Outcomes

Few studies have investigated patient‐reported outcomes (PRO) and patient‐reported experience (PRE) with the use of s‐CAIS [106, 107]. A randomised study by Amorfini et al. showed that patients expressed significantly higher confidence in s‐CAIS compared to the non‐guided group prior to the surgery, although both groups reported similar overall satisfaction afterwards [99]. A retrospective study by Youk et al. showed that s‐CAIS patients reported less discomfort, reduced emotional distress, and higher satisfaction compared to free‐hand surgery but brought up the issue of financial burden associated with the cost of CAIS [108].

Studies including both flap and flapless implant surgeries have found no statistically significant difference in intraoperative pain between patients operated on with s‐CAIS and those undergoing the free‐hand procedure [109, 110, 111]. However, when flapless surgery was combined with s‐CAIS, patients reported lower intra‐operative and post‐operative pain levels and consumed less post‐operative analgesic compared to conventional, open flap approaches [59, 75, 112, 113, 114]. Furthermore, higher patient satisfaction with overall treatment outcomes appears to be associated more with the presence of immediate restoration [99, 105], especially in the aesthetic zone.

1.5. Education and Training

Clinicians need to undergo specific training to effectively apply the s‐CAIS workflow in practice, which extends from the data collection to digital treatment planning and execution of guided implant surgery including troubleshooting and quality assurance of all stages. The actual execution of surgery using a surgical guide does not appear to be a highly demanding task, often depicted with a learning curve of increasing returns [115], suggesting that clinicians can reach the accuracy “plateau” after relatively little training and time on task. s‐CAIS has the potential to narrow the performance gap in implant placement accuracy between experienced and novice surgeons. A number of small sample studies found no difference in the accuracy with s‐CAIS regardless of the experience level of the surgeon, while some showed higher deviation in inexperienced surgeons in the coronal, bucco‐lingual direction and implant angulation [116, 117, 118]. Nevertheless, even if s‐CAIS can help inexperienced operators reach higher accuracy [111], it should not be perceived as compensation for the lack of experience or spatial representation ability [119] but rather as the means to increase reproducibility and efficiency of a procedure the surgeon is fully competent to design and perform freehand if needed [120]. In addition, as s‐CAIS limits the tactile proprioception of the operator and the visualisation of anatomy, it is also reported to be an inferior learning experience for the novice practitioners compared to freehand surgery [121]. Therefore, s‐CAIS might provide greater clinical value at a more advanced stages of training, particularly after proficiency in freehand implant placement is established and procedural optimisation becomes the primary focus.

1.6. Advantages and Limitations

1.6.1. Advantages of s‐CAIS Over Non‐Guided

Compared to conventional techniques, s‐CAIS can significantly improve the trueness of implant placement and reduce the duration of complex surgeries, potentially contributing to increased patient satisfaction. By enhancing accuracy and predictability, s‐CAIS could reduce surgical risks and morbidity in anatomically critical regions, such as nerves, vessels, maxillary sinus, and adjacent tooth roots. With a preceding meticulously crafted bio‐restorative digital treatment plan, guided placement could empower immediacy protocols with prefabricated prosthesis, facilitate the use of minimally invasive protocols (e.g., flapless approach) [59, 101, 106, 112, 113, 114], as well as avoid short‐and long‐term complications [122].

1.6.2. Advantages of s‐CAIS Over d‐CAIS

Currently, the primary comparative advantages of s‐CAIS over d‐CAIS include a significantly smaller initial investment, simpler device componentry, and the relatively easier training and mastery. S‐CAIS is widely adopted and available at a lower cost for patients. Having a surgical guide in place expedites the determination of the entry point of the pilot drill and subsequent drills and increases implant platform accuracy compared to d‐CAIS [46]. The combination of s‐ and d‐CAIS techniques may help to ease the learning curve process for dynamic navigation while the operator achieves the level of hand‐eye‐screen coordination required.

1.6.3. Limitations

S‐CAIS comes with an array of contraindications and limitations. The use of s‐CAIS is contraindicated in cases with restricted mouth opening, patients with excessive gag reflex, or limited interocclusal space, where the insertion of the surgical guide with the drill and handpiece simultaneously might be challenging or impossible. Further limitations might include the application in narrow gaps (< 5 mm, typical diameter of sleeve) or where an unusually long implant has been planned (14 mm or more). The surgical guide may also restrict the access of irrigation to the osteotomy site [123, 124, 125] (Figure 9). Using drills with internal irrigation, incorporating a buccal opening near the sleeve, or employing a separate irrigation syringe with the tip positioned between the guide and the bone may help deliver irrigation better to the osteotomy site.

FIGURE 9.

FIGURE 9

Mucosa‐supported surgical guide retained by pins—note how a well‐fitted drill in the metal sleeve prevents irrigation from the handpiece from reaching the other side of the stent.

Furthermore, there is no real‐time visualisation of the implant trajectory or surgical site. Likewise, the operator's tactile sensitivity and proprioception of the bone quality may decrease, which might conceal bony defects such as dehiscence, low bone density, or reduced primary stability [7]. In addition, intraoperative adjustments of the implant position or angle are not possible unless the surgical guide is abandoned [126]. Reportedly, implants placed with static surgical guides tend to be inserted 0.5–1.5 mm shallower than planned, particularly when following the fully guided protocol. This could result in a wide emergence angle, impairing oral hygiene and affecting marginal bone levels [127].

Cost may also be a barrier for s‐CAIS uptake among clinicians and patients. S‐CAIS requires the use of implant planning software usually available with a licensing fee, intraoral or lab scanners, a guided surgery kit, and the cost of the surgical guide, all of which would be transferred to the patient and reflected in higher treatment costs.

Most importantly, the benefits of s‐CAIS are only relevant if the planning of the implant surgery has been carried out correctly; otherwise, the accuracy and benefits afforded by s‐CAIS would be rendered meaningless.

1.7. Future Directions and Potentials

Although s‐CAIS has evolved significantly since its inception, its fundamental principles remain unchanged; progress has been driven mainly by incremental refinement of the componentry. The use of GISS and GISK has reached the level of an affordable, accessible, and predictable technology to assist accurate implant placement. At the same time, the absence of a qualitative breakthrough and the relative paucity of evolution and development in this field speaks of a technology that has reached its peak potential. Incremental improvements in accuracy or efficiency are still possible through the evolution of 3D printing technology and improvements in the printable materials; however, these developments are unlikely to produce transformative changes in the clinical performance of static guides.

The field of digital treatment plan is undergoing rapid transformation, with artificial intelligence‐powered software demonstrating significant potential to automate repetitive tasks such as 3D image segmentation and alignment while actively generating treatment plans and customised components. Importantly, these advancements are applicable to enhance all CAIS workflows, beyond static guidance. At the same time, the seamless execution of the digital treatment plan is hampered by the limited interoperability between different software and devices [120].

Manufacturers of digital services, software and devices should prioritise open and collaborative workflows which enable seamless integration of implant planning into broader treatment workflows; for example, by accommodating orthodontic tooth movement projections during implant space planning. Cross‐platform interoperability, elimination of proprietary barriers that currently fragment comprehensive treatment workflows and clinician ownership of the digital treatment plan will allow the true multi‐disciplinary approach, essential in complex cases.

Recent clinical trials [52, 128, 129, 130], including a network meta‐analysis [56], have demonstrated that a surgical guide, when combined with a navigation system, could further reduce implant position deviation as compared to the use of either technology alone. Still, it is doubtful if this combination would have indications in mainstream clinical practice, as this incremental increase in trueness comes at a significant cost in terms of time in preparation and on task, costs, and facilities. Furthermore, patient‐specific factors and clinical indications may exclude a higher proportion of cases from s‐CAIS suitability compared to the d‐CAIS alternative.

Following known paths of maturation of innovative technologies, navigation systems are bound to become more affordable, more compact, and expand their scope of indications. While these advancements may decrease the overall reliance on s‐CAIS, it is anticipated that s‐CAIS will continue to serve as the primary modality of guided implant placement in the foreseeable future.

2. Discussion

After development of 25 years since its initial inception, s‐CAIS has been established as a reliable and affordable workflow for placing dental implants with high accuracy. Its use can increase the efficacy and efficiency of dental implant therapy, facilitate treatment protocols of higher complexity, and improve treatment outcomes and patient experience. At the same time, it is currently difficult to envision significant improvements in the devices or protocols of s‐CAIS, which is suggestive of a technology that has reached its maturity.

Accuracy of implant placement has been the most studied outcome with regards to s‐CAIS, but also any other technology of guided implant surgery. Nevertheless, despite the plethora of research on accuracy, the actual threshold at which accuracy translates to substantial clinical benefits for the intended treatment remains unclear. Increasing accuracy is an important clinical parameter for the success of well‐planned interventions, as accurately placed implants as part of a bio‐restorative, prosthetically driven treatment plan have better marginal bone stability, aesthetics and long‐term prognosis with lower rates of biological and mechanical complications [122]. At the same time, the relentless drive towards zero deviation might be more of an academic pursuit, especially when the critical thresholds of accuracy essential for the desired clinical outcomes are largely unknown. Future studies in CAIS might need to divert focus from the accuracy achieved to the actual clinical outcomes [7], for example how frequently the use of s‐CAIS allows the seamless placement of prefabricated prosthesis or how frequently extensive modifications are required. Future research should also investigate education and training efficiency, as well as patient experience with the actual clinical outcomes that s‐CAIS can empower, rather than comparing isolated surgical procedures [107].

With multiple implant companies offering guided surgery systems featuring subtly different surgical kits, it can be confusing even for experienced clinicians to choose a system to adopt. Since the core workflow concept is consistent across systems, clinicians would benefit from structured training on the s‐CAIS workflow, including its potential and limitations. Experimenting with different GISS would then allow for a more informed selection and adaptation of the proper tools. While s‐CAIS could increase efficiency and shorten the duration of surgical intervention, the on‐screen time spent on digital implant treatment plan and guide design is often overlooked. This process requires training and could be time‐consuming; thus, it is often a deterrent for experienced clinicians who have been achieving consistently good results with non‐guided surgery. Mastering digital implant treatment planning requires different levels of effort for each clinician, influenced by their personal motivation and the intuitiveness of the software used. Artificial intelligence and algorithms based on machine learning are envisioned to undertake much of the digital treatment planning in the near future, automating the process and reducing the burden for the clinician. It is recommended to try out a few software solutions [131] before investing in one and incorporating it into the workflow. It is also crucial to choose an open platform to enable collaboration in cases involving a more complex workflow and to keep abreast of the latest developments in digital technologies in general. Outsourcing the task of digital treatment plan and guide design to a laboratory or a central production facility [131] might be a viable option, albeit with cost implications. Even so, the clinician maintains full responsibility for the plan and designs; thus, one should be at least competent to review the treatment plan and guide designs, confirm the level of quality, and adherence to biological principles and technical standards. Since patients ultimately bear these costs, the anticipated benefits must clearly justify them, and the parameter of cost‐effectiveness requires further investigation.

3. Conclusion

Despite its limitations, s‐CAIS has become the established standard for guided implant placement, serving as the benchmark for comparison for all other technologies. Although technologies and workflows such as d‐CAIS and r‐CAIS have shown promising results in terms of the accuracy of implant placement, each comes with its own challenges and limitations. Thus, s‐CAIS is anticipated to remain the dominant modality for guided implant placement in the foreseeable future, albeit with declining importance.

Conflicts of Interest

The authors declare no conflicts of interest.

Acknowledgements

The authors gratefully acknowledge Dr. Peiman Yazdani, Dr. Jarungvit Lorwicheanrung, Dr. Keyvan Sagheb and Dr. Moataz Bayadse for generously contributing clinical photographs to this manuscript, which significantly enhanced the visual documentation and educational value of this work.

Data Availability Statement

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

References

  • 1. Jorba‐Garcia A., Pozzi A., Chen Z., et al., “Glossary of Computer‐Assisted Implant Surgery and Related Terms. First Edition,” Clinical and Experimental Dental Research 11, no. 4 (2025): e70148, 10.1002/cre2.70148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2. Pedrinaci I., Hamilton A., Lanis A., Sanz M., and Gallucci G., “The Bio‐Restorative Concept for Implant‐Supported Restorations,” Journal of Esthetic and Restorative Dentistry 36 (2024): 1516–1527. [DOI] [PubMed] [Google Scholar]
  • 3. Puisys A., Janda M., Auzbikaviciute V., Gallucci G. O., and Mattheos N., “Contour Angle and Peri‐Implant Tissue Height: Two Interrelated Features of the Implant Supracrestal Complex,” Clinical and Experimental Dental Research 9, no. 3 (2023): 418–424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4. Janda M. and Mattheos N., “Prosthetic Design and Choice of Components for Maintenance of Optimal Peri‐Implant Health: A Comprehensive Review,” British Dental Journal 236, no. 10 (2024): 765–771. [DOI] [PubMed] [Google Scholar]
  • 5. Verstreken K., van Cleynenbreugel J., Martens K., Marchal G., van Steenberghe D., and Suetens P., “An Image‐Guided Planning System for Endosseous Oral Implants,” IEEE Transactions on Medical Imaging 17, no. 5 (1998): 842–852. [DOI] [PubMed] [Google Scholar]
  • 6. Brånemark P. I., Engstrand P., Ohrnell L. O., et al., “Brånemark Novum: A New Treatment Concept for Rehabilitation of the Edentulous Mandible. Preliminary Results From a Prospective Clinical Follow‐Up Study,” Clinical Implant Dentistry and Related Research 1, no. 1 (1999): 2–16. [DOI] [PubMed] [Google Scholar]
  • 7. Sadilina S., Vietor K., Doliveux R., et al., “Beyond Accuracy: Clinical Outcomes of Computer Assisted Implant Surgery,” Clinical and Experimental Dental Research 11, no. 3 (2025): e70129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8. Pimkhaokham A., Jiaranuchart S., Kaboosaya B., Arunjaroensuk S., Subbalekha K., and Mattheos N., “Can Computer‐Assisted Implant Surgery Improve Clinical Outcomes and Reduce the Frequency and Intensity of Complications in Implant Dentistry? A Critical Review,” Periodontology 2000 90, no. 1 (2000): 197–223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. Gargallo‐Albiol J., Barootchi S., Marqués‐Guasch J., and Wang H. L., “Fully Guided Versus Half‐Guided and Freehand Implant Placement: Systematic Review and Meta‐Analysis,” International Journal of Oral & Maxillofacial Implants 35, no. 6 (2020): 1159–1169. [DOI] [PubMed] [Google Scholar]
  • 10. Bover‐Ramos F., Viña‐Almunia J., Cervera‐Ballester J., Peñarrocha‐Diago M., and García‐Mira B., “Accuracy of Implant Placement With Computer‐Guided Surgery: A Systematic Review and Meta‐Analysis Comparing Cadaver, Clinical, and In Vitro Studies,” International Journal of Oral & Maxillofacial Implants 33, no. 1 (2018): 101–115. [DOI] [PubMed] [Google Scholar]
  • 11. Younes F., Cosyn J., de Bruyckere T., Cleymaet R., Bouckaert E., and Eghbali A., “A Randomized Controlled Study on the Accuracy of Free‐Handed, Pilot‐Drill Guided and Fully Guided Implant Surgery in Partially Edentulous Patients,” Journal of Clinical Periodontology 45, no. 6 (2018): 721–732. [DOI] [PubMed] [Google Scholar]
  • 12. Bencharit S., Staffen A., Yeung M., Whitley D., Laskin D. M., and Deeb G. R., “In Vivo Tooth‐Supported Implant Surgical Guides Fabricated With Desktop Stereolithographic Printers: Fully Guided Surgery Is More Accurate Than Partially Guided Surgery,” Journal of Oral and Maxillofacial Surgery 76, no. 7 (2018): 1431–1439. [DOI] [PubMed] [Google Scholar]
  • 13. Putra R. H., Yoda N., Astuti E. R., and Sasaki K., “The Accuracy of Implant Placement With Computer‐Guided Surgery in Partially Edentulous Patients and Possible Influencing Factors: A Systematic Review and Meta‐Analysis,” Journal of Prosthodontic Research 66, no. 1 (2022): 29–39. [DOI] [PubMed] [Google Scholar]
  • 14. Behneke A., Burwinkel M., and Behneke N., “Factors Influencing Transfer Accuracy of Cone Beam CT‐Derived Template‐Based Implant Placement,” Clinical Oral Implants Research 23, no. 4 (2012): 416–423. [DOI] [PubMed] [Google Scholar]
  • 15. Zhou W., Liu Z., Song L., Kuo C. L., and Shafer D. M., “Clinical Factors Affecting the Accuracy of Guided Implant Surgery—A Systematic Review and Meta‐Analysis,” Journal of Evidence‐Based Dental Practice 18, no. 1 (2018): 28–40. [DOI] [PubMed] [Google Scholar]
  • 16. Matsumura A., Nakano T., Ono S., Kaminaka A., Yatani H., and Kabata D., “Multivariate Analysis of Causal Factors Influencing Accuracy of Guided Implant Surgery for Partial Edentulism: A Retrospective Clinical Study,” International Journal of Implant Dentistry 7 (2021): 28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Markovic J., Peña‐Cardelles J. F., Pedrinaci I., Hamilton A., Gallucci G. O., and Lanis A., “Considerations for Predictable Outcomes in Static Computer‐ Aided Implant Surgery in the Esthetic Zone,” Journal of Esthetic and Restorative Dentistry 36, no. 1 (2024): 207–219. [DOI] [PubMed] [Google Scholar]
  • 18. Cawood J. I. and Howell R. A., “A Classification of the Edentulous Jaws,” International Journal of Oral and Maxillofacial Surgery 17, no. 4 (1988): 232–236. [DOI] [PubMed] [Google Scholar]
  • 19. Lan R., Marteau C., Mense C., and Silvestri F., “Current Knowledge About Stackable Guides: A Scoping Review,” International Journal of Implant Dentistry 10, no. 1 (2024): 28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Lu J. Y., Yu J. Y., Xie C. Y., Gao J., and Yu H. Y., “Immediate Precision of the Digital Osteotomy Template in the Digital Stackable Template: A Clinical Study,” Hua Xi Kou Qiang Yi Xue Za Zhi 39, no. 6 (2021): 732–738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Osman A. H., Mansour H., Atef M., and Hakam M., “Computer Guided Sinus Floor Elevation Through Lateral Window Approach With Simultaneous Implant Placement,” Clinical Implant Dentistry and Related Research 20, no. 2 (2018): 137–143. [DOI] [PubMed] [Google Scholar]
  • 22. Mandelaris G. A. and Rosenfeld A. L., “Alternative Applications of Guided Surgery: Precise Outlining of the Lateral Window in Antral Sinus Bone Grafting,” Journal of Oral and Maxillofacial Surgery 67, no. 11 Suppl (2009): 23–30. [DOI] [PubMed] [Google Scholar]
  • 23. Narongchai N., Arunjaroensuk S., Subbalekha K., Kamolratanakul P., Pimkhaokham A., and Mattheos N., “Patient‐Reported Healing of Static Computer‐Assisted Sinus Lateral Window Osteotomy: A Randomized Controlled Trial,” Clinical Implant Dentistry and Related Research 27, no. 3 (2025): e70057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24. Zhang X., Wang J., Wan Q., and Li L., “Guided Residual Root Preparation for Socket‐Shield Procedures: A Clinical Report,” Journal of Prosthetic Dentistry 124, no. 6 (2020): 625–631. [DOI] [PubMed] [Google Scholar]
  • 25. Zhu G., Froum S. J., Praisonta S., et al., “A Modified Socket‐Shield Technique: Simplifying the Root Sectioning Process,” Compendium of Continuing Education in Dentistry 45, no. 4 (2024): 199–202. [PubMed] [Google Scholar]
  • 26. Schiroli G., Angiero F., Silvestrini‐Biavati A., and Benedicenti S., “Zygomatic Implant Placement With Flapless Computer‐Guided Surgery: A Proposed Clinical Protocol,” Journal of Oral and Maxillofacial Surgery 69, no. 12 (2011): 2979–2989. [DOI] [PubMed] [Google Scholar]
  • 27. van Steenberghe D., Malevez C., van Cleynenbreugel J., et al., “Accuracy of Drilling Guides for Transfer From Three‐Dimensional CT‐Based Planning to Placement of Zygoma Implants in Human Cadavers,” Clinical Oral Implants Research 14, no. 1 (2003): 131–136. [DOI] [PubMed] [Google Scholar]
  • 28. Grecchi E., Stefanelli L. V., Grecchi F., Grivetto F., Franchina A., and Pranno N., “A Novel Guided Zygomatic Implant Surgery System Compared to Free Hand: A Human Cadaver Study on Accuracy,” Journal of Dentistry 119 (2022): 103942. [DOI] [PubMed] [Google Scholar]
  • 29. Chrcanovic B. R., Oliveira D. R., and Custódio A. L., “Accuracy Evaluation of Computed Tomography–Derived Stereolithographic Surgical Guides in Zygomatic Implant Placement in Human Cadavers,” Journal of Oral Implantology 36, no. 5 (2010): 345–355. [DOI] [PubMed] [Google Scholar]
  • 30. Vrielinck L., Politis C., Schepers S., Pauwels M., and Naert I., “Image‐Based Planning and Clinical Validation of Zygoma and Pterygoid Implant Placement in Patients With Severe Bone Atrophy Using Customized Drill Guides. Preliminary Results From a Prospective Clinical Follow‐Up Study,” International Journal of Oral and Maxillofacial Surgery 32, no. 1 (2003): 7–14. [DOI] [PubMed] [Google Scholar]
  • 31. Wang C. I., Cho S.‐H., Cho D., Ducote C., Reddy L. V., and Sinada N., “A 3D‐Printed Guide to Assist in Sinus Slot Preparation for the Optimization of Zygomatic Implant Axis Trajectory,” Journal of Prosthodontics 29, no. 2 (2020): 179–184. [DOI] [PubMed] [Google Scholar]
  • 32. Gallo F., Zingari F., Bolzoni A., Barone S., and Giudice A., “Accuracy of Zygomatic Implant Placement Using a Full Digital Planning and Custom‐Made Bone‐Supported Guide: A Retrospective Observational Cohort Study,” Dentistry Journal 11, no. 5 (2023): 123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33. Chow J., “A Novel Device for Template‐Guided Surgery of the Zygomatic Implants,” International Journal of Oral and Maxillofacial Surgery 45, no. 10 (2016): 1253–1255. [DOI] [PubMed] [Google Scholar]
  • 34. Bolzoni A. R., Zingari F., Gallo F., et al., “Zygomatic Implant Guided Rehabilitation Based on Inverted Support Technique: A Pilot Study,” European Review for Medical and Pharmacological Sciences 27, no. 3 Suppl (2023): 77–91. [DOI] [PubMed] [Google Scholar]
  • 35. Vosselman N., Glas H. H., Merema B. J., et al., “Three‐Dimensional Guided Zygomatic Implant Placement After Maxillectomy,” Journal of Personalized Medicine 12, no. 4 (2022): 588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36. Vosselman N., Glas H. H., de Visscher S. A. H. J., et al., “Immediate Implant‐Retained Prosthetic Obturation After Maxillectomy Based on Zygomatic Implant Placement by 3D‐Guided Surgery: A Cadaver Study,” International Journal of Implant Dentistry 7, no. 1 (2021): 54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37. Fan S., Sáenz‐Ravello G., Diaz L., et al., “The Accuracy of Zygomatic Implant Placement Assisted by Dynamic Computer‐Aided Surgery: A Systematic Review and Meta‐Analysis,” Journal of Clinical Medicine 12, no. 16 (2023): 5418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38. Ozan O., Turkyilmaz I., Ersoy A. E., McGlumphy E. A., and Rosenstiel S. F., “Clinical Accuracy of 3 Different Types of Computed Tomography‐Derived Stereolithographic Surgical Guides in Implant Placement,” Journal of Oral and Maxillofacial Surgery 67, no. 2 (2009): 394–401. [DOI] [PubMed] [Google Scholar]
  • 39. Accuracy (Trueness and Precision) of Measurement Methods and Results—Part 1: General Principles and Definitions, https://www.iso.org/obp/ui/#iso:std:iso:5725:‐1:ed‐2:v1:en.
  • 40. Guentsch A., Sukhtankar L., An H., and Luepke P. G., “Precision and Trueness of Implant Placement With and Without Static Surgical Guides: An In Vitro Study,” Journal of Prosthetic Dentistry 126, no. 3 (2021): 398–404. [DOI] [PubMed] [Google Scholar]
  • 41. Pattanasirikun P., Arunjaroensuk S., Panya S., Subbalekha K., Mattheos N., and Pimkhaokham A., “Comparison of Precision of Implant Placement Between Two Different Guided Systems for Static Computer‐Assisted Implant Surgery: A Simulation‐Based Experimental Study,” Journal of Dental Sciences 19 (2024): S38–S43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 42. Adams C. R., Ammoun R., Deeb G. R., and Bencharit S., “Influence of Metal Guide Sleeves on the Accuracy and Precision of Dental Implant Placement Using Guided Implant Surgery: An In Vitro Study,” Journal of Prosthodontics 32, no. 1 (2023): 62–70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 43. Yeung M., Abdulmajeed A., Carrico C. K., Deeb G. R., and Bencharit S., “Accuracy and Precision of 3D‐Printed Implant Surgical Guides With Different Implant Systems: An In Vitro Study,” Journal of Prosthetic Dentistry 123, no. 6 (2020): 821–828. [DOI] [PubMed] [Google Scholar]
  • 44. Tahmaseb A., Wu V., Wismeijer D., Coucke W., and Evans C., “The Accuracy of Static Computer‐Aided Implant Surgery: A Systematic Review and Meta‐Analysis,” Clinical Oral Implants Research 29, no. Suppl 16 (2018): 416–435. [DOI] [PubMed] [Google Scholar]
  • 45. Khaohoen A., Powcharoen W., Yoda N., Rungsiyakull C., and Rungsiyakull P., “Accuracy in Dental Implant Placement: A Systematic Review and Meta‐Analysis Comparing Computer‐Assisted (Static, Dynamic, Robotics) and Noncomputer‐Assisted (Freehand, Conventional Guide) Approaches,” Journal of Prosthetic Dentistry 134, no. 1 (2025): 91.e1–91.e25, 10.1016/j.prosdent.2025.03.038. [DOI] [PubMed] [Google Scholar]
  • 46. Werny J. G., Frank K., Fan S., et al., “Freehand vs. Computer‐Aided Implant Surgery: A Systematic Review and Meta‐Analysis‐Part 1: Accuracy of Planned and Placed Implant Position,” International Journal of Implant Dentistry 11, no. 1 (2025): 35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47. Marques‐Guasch J., Bofarull‐Ballús A., Giralt‐Hernando M., Hernández‐Alfaro F., and Gargallo‐Albiol J., “Dynamic Implant Surgery—An Accurate Alternative to Stereolithographic Guides‐Systematic Review and Meta‐Analysis,” Dentistry Journal 11, no. 6 (2023): 150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 48. Pimkhaokham A., Chow J., Pozzi A., Arunjaroensuk S., Subbalehka K., and Mattheos N., “Computer‐Assisted and Robotic Implant Surgery: Assessing the Outcome Measures of Accuracy and Educational Implications,” Clinical Oral Implants Research 35, no. 8 (2024): 939–953. [DOI] [PubMed] [Google Scholar]
  • 49. Van Assche N., Vercruyssen M., Coucke W., Teughels W., Jacobs R., and Quirynen M., “Accuracy of Computer‐Aided Implant Placement,” Clinical Oral Implants Research 23, no. Suppl 6 (2012): 112–123. [DOI] [PubMed] [Google Scholar]
  • 50. Verhamme L. M., Meijer G. J., Bergé S. J., et al., “An Accuracy Study of Computer‐Planned Implant Placement in the Augmented Maxilla Using Mucosa‐Supported Surgical Templates,” Clinical Implant Dentistry and Related Research 17, no. 6 (2015): 1154–1163. [DOI] [PubMed] [Google Scholar]
  • 51. Lin C. C., Ishikawa M., Maida T., et al., “Stereolithographic Surgical Guide With a Combination of Tooth and Bone Support: Accuracy of Guided Implant Surgery in Distal Extension Situation,” Journal of Clinical Medicine 9, no. 3 (2020): 709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 52. Yotpibulwong T., Arunjaroensuk S., Kaboosaya B., et al., “Accuracy of Implant Placement With a Combined Use of Static and Dynamic Computer‐Assisted Implant Surgery in Single Tooth Space: A Randomized Controlled Trial,” Clinical Oral Implants Research 34, no. 4 (2023): 330–341. [DOI] [PubMed] [Google Scholar]
  • 53. Jorba‐García A., González‐Barnadas A., Camps‐Font O., Figueiredo R., and Valmaseda‐Castellón E., “Accuracy Assessment of Dynamic Computer‐Aided Implant Placement: A Systematic Review and Meta‐Analysis,” Clinical Oral Investigations 25, no. 5 (2021): 2479–2494. [DOI] [PubMed] [Google Scholar]
  • 54. Yu X., Tao B., Wang F., and Wu Y., “Accuracy Assessment of Dynamic Navigation During Implant Placement: A Systematic Review and Meta‐Analysis of Clinical Studies in the Last 10 Years,” Journal of Dentistry 135 (2023): 104567. [DOI] [PubMed] [Google Scholar]
  • 55. Vinnakota D. N., Kamatham R., Nagaraj E., and Reddy P. S., “Is Dynamic Computer‐Assisted Surgery More Accurate Than the Static Method for Dental Implant Placement? A Systematic Review and Meta‐Analysis,” Journal of Prosthetic Dentistry 133, no. 6 (2025): 1448–1460. [DOI] [PubMed] [Google Scholar]
  • 56. Mahardawi B., Jiaranuchart S., Arunjaroensuk S., Dhanesuan K., Mattheos N., and Pimkhaokham A., “The Accuracy of Dental Implant Placement With Different Methods of Computer‐Assisted Implant Surgery: A Network Meta‐Analysis of Clinical Studies,” Clinical Oral Implants Research 36 (2025): 1–16. [DOI] [PubMed] [Google Scholar]
  • 57. Pozzi A., Polizzi G., and Moy P. K., “Guided Surgery With Tooth‐Supported Templates for Single Missing Teeth: A Critical Review,” European Journal of Oral Implantology 9, no. S1 (2016): S135–S153. [PubMed] [Google Scholar]
  • 58. Raico Gallardo Y. N., da Silva‐Olivio I. R. T., Mukai E., Morimoto S., Sesma N., and Cordaro L., “Accuracy Comparison of Guided Surgery for Dental Implants According to the Tissue of Support: A Systematic Review and Meta‐Analysis,” Clinical Oral Implants Research 28, no. 5 (2017): 602–612. [DOI] [PubMed] [Google Scholar]
  • 59. Arısan V., Karabuda C. Z., and Özdemir T., “Implant Surgery Using Bone‐ and Mucosa‐Supported Stereolithographic Guides in Totally Edentulous Jaws: Surgical and Post‐Operative Outcomes of Computer‐Aided vs. Standard Techniques,” Clinical Oral Implants Research 21, no. 9 (2010): 980–988. [DOI] [PubMed] [Google Scholar]
  • 60. Vercruyssen M., Cox C., Coucke W., Naert I., Jacobs R., and Quirynen M., “A Randomized Clinical Trial Comparing Guided Implant Surgery (Bone‐ or Mucosa‐Supported) With Mental Navigation or the Use of a Pilot‐Drill Template,” Journal of Clinical Periodontology 41, no. 7 (2014): 717–723. [DOI] [PubMed] [Google Scholar]
  • 61. Nguyen M., Nguyen H. K. K., Nguyen T. N., and Huynh N. C.‐N., “Influence of Supporting Teeth Quantity of Surgical Guide on the Accuracy of the Immediate Implant in the Maxillary Central Incisor: An In Vitro Study,” BDJ Open 10, no. 1 (2024): 100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 62. el Kholy K., Janner S. F. M., Schimmel M., and Buser D., “The Influence of Guided Sleeve Height, Drilling Distance, and Drilling Key Length on the Accuracy of Static Computer‐Assisted Implant Surgery,” Clinical Implant Dentistry and Related Research 21, no. 1 (2019): 101–107. [DOI] [PubMed] [Google Scholar]
  • 63. el Kholy K., Lazarin R., Janner S. F. M., Faerber K., Buser R., and Buser D., “Influence of Surgical Guide Support and Implant Site Location on Accuracy of Static Computer‐Assisted Implant Surgery,” Clinical Oral Implants Research 30, no. 11 (2019): 1067–1075. [DOI] [PubMed] [Google Scholar]
  • 64. Henprasert P., Dawson D. V., El‐Kerdani T., Song X., Couso‐Queiruga E., and Holloway J. A., “Comparison of the Accuracy of Implant Position Using Surgical Guides Fabricated by Additive and Subtractive Techniques,” Journal of Prosthodontics 29, no. 6 (2020): 534–541. [DOI] [PubMed] [Google Scholar]
  • 65. Mukai S., Mukai E., Santos‐Junior J. A., Shibli J. A., Faveri M., and Giro G., “Assessment of the Reproducibility and Precision of Milling and 3D Printing Surgical Guides,” BMC Oral Health 21, no. 1 (2021): 1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 66. Keßler A., Dosch M., Reymus M., and Folwaczny M., “Influence of 3D‐Printing Method, Resin Material, and Sterilization on the Accuracy of Virtually Designed Surgical Implant Guides,” Journal of Prosthetic Dentistry 128, no. 2 (2022): 196–204. [DOI] [PubMed] [Google Scholar]
  • 67. Shi Y., Wang J., Ma C., Shen J., Dong X., and Lin D., “A Systematic Review of the Accuracy of Digital Surgical Guides for Dental Implantation,” International Journal of Implant Dentistry 9, no. 1 (2023): 38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 68. Abduo J. and Lau D., “Effect of Manufacturing Technique on the Accuracy of Surgical Guides for Static Computer‐Aided Implant Surgery,” International Journal of Oral & Maxillofacial Implants 35, no. 5 (2020): 931–938. [DOI] [PubMed] [Google Scholar]
  • 69. Bathija A., Papaspyridakos P., Finkelman M., Kim Y., Kang K., and De Souza A. B., “Accuracy of Static Computer‐Aided Implant Surgery (S‐CAIS) Using CAD‐CAM Surgical Templates Fabricated From Different Additive Manufacturing Technologies,” Journal of Prosthetic Dentistry 133, no. 2 (2025): 524–529. [DOI] [PubMed] [Google Scholar]
  • 70. Herschdorfer L., Negreiros W. M., Gallucci G. O., and Hamilton A., “Comparison of the Accuracy of Implants Placed With CAD‐CAM Surgical Templates Manufactured With Various 3D Printers: An In Vitro Study,” Journal of Prosthetic Dentistry 125, no. 6 (2021): 905–910. [DOI] [PubMed] [Google Scholar]
  • 71. Ersoy A. E., Turkyilmaz I., Ozan O., and McGlumphy E. A., “Reliability of Implant Placement With Stereolithographic Surgical Guides Generated From Computed Tomography: Clinical Data From 94 Implants,” Journal of Periodontology 79, no. 8 (2008): 1339–1345. [DOI] [PubMed] [Google Scholar]
  • 72. van Assche N., van Steenberghe D., Guerrero M. E., et al., “Accuracy of Implant Placement Based on Pre‐Surgical Planning of Three‐Dimensional Cone‐Beam Images: A Pilot Study,” Journal of Clinical Periodontology 34, no. 9 (2007): 816–821. [DOI] [PubMed] [Google Scholar]
  • 73. Sigcho López D. A., García I., da Silva Salomao G., and Cruz Laganá D., “Potential Deviation Factors Affecting Stereolithographic Surgical Guides: A Systematic Review,” Implant Dentistry 28, no. 1 (2019): 68–73. [DOI] [PubMed] [Google Scholar]
  • 74. Raabe C., Schuetz T. S., Chappuis V., Yilmaz B., Abou‐Ayash S., and Couso‐Queiruga E., “Accuracy of Keyless vs Drill‐Key Implant Systems for Static Computer‐Assisted Implant Surgery Using Two Guide‐Hole Designs Compared to Freehand Implant Placement: An In Vitro Study,” International Journal of Implant Dentistry 9, no. 1 (2023): 4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 75. Romandini M., Ruales‐Carrera E., Sadilina S., Hämmerle C. H. F., and Sanz M., “Minimal Invasiveness at Dental Implant Placement: A Systematic Review With Meta‐Analyses on Flapless Fully Guided Surgery,” Periodontology 2000 91, no. 1 (2023): 89–112. [DOI] [PubMed] [Google Scholar]
  • 76. Floriani F., Jurado C. A., Cabrera A. J., Duarte W., Porto T. S., and Afrashtehfar K. I., “Depth Distortion and Angular Deviation of a Fully Guided Tooth‐Supported Static Surgical Guide in a Partially Edentulous Patient: A Systematic Review and Meta‐Analysis,” Journal of Prosthodontics 33, no. S1 (2024): 10–24. [DOI] [PubMed] [Google Scholar]
  • 77. Dulla F. A., Couso‐Queiruga E., Chappuis V., Yilmaz B., Abou‐Ayash S., and Raabe C., “Influence of Alveolar Ridge Morphology and Guide‐Hole Design on the Accuracy of Static Computer‐Assisted Implant Surgery With Two Implant Macro‐Designs: An In Vitro Study,” Journal of Dentistry 130 (2023): 104426. [DOI] [PubMed] [Google Scholar]
  • 78. Hang J. and Guentsch A., “Are Sleeves Necessary in Static Computer‐Assisted Implant Surgery? A Comparative In Vitro Analysis,” Clinical Oral Implants Research 36, no. 1 (2025): 117–126. [DOI] [PubMed] [Google Scholar]
  • 79. Raabe C., Dulla F. A., Yilmaz B., Chappuis V., and Abou‐Ayash S., “Influence of Drilling Sequence and Guide‐Hole Design on the Accuracy of Static Computer‐Assisted Implant Surgery in Extraction Sockets and Healed Sites‐An In Vitro Investigation,” Clinical Oral Implants Research 34, no. 4 (2023): 320–329. [DOI] [PubMed] [Google Scholar]
  • 80. Sittikornpaiboon P., Arunjaroensuk S., Kaboosaya B., Subbalekha K., Mattheos N., and Pimkhaokham A., “Comparison of the Accuracy of Implant Placement Using Different Drilling Systems for Static Computer‐Assisted Implant Surgery: A Simulation‐Based Experimental Study,” Clinical Implant Dentistry and Related Research 23, no. 4 (2021): 635–643. [DOI] [PubMed] [Google Scholar]
  • 81. Tallarico M., Czajkowska M., Cicciù M., et al., “Accuracy of Surgical Templates With and Without Metallic Sleeves in Case of Partial Arch Restorations: A Systematic Review,” Journal of Dentistry 115 (2021): 103852. [DOI] [PubMed] [Google Scholar]
  • 82. Tallarico M., Martinolli M., Kim Y.‐J., et al., “Accuracy of Computer‐Assisted Template‐Based Implant Placement Using Two Different Surgical Templates Designed With or Without Metallic Sleeves: A Randomized Controlled Trial,” Dentistry Journal 7, no. 2 (2019): 41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 83. Tallarico M., Kim Y.‐J., Cocchi F., Martinolli M., and Meloni S. M., “Accuracy of Newly Developed Sleeve‐Designed Templates for Insertion of Dental Implants: A Prospective Multicenters Clinical Trial,” Clinical Implant Dentistry and Related Research 21, no. 1 (2019): 108–113. [DOI] [PubMed] [Google Scholar]
  • 84. Li J., Meneghetti P. C., Galli M., Mendonca G., Chen Z., and Wang H. L., “Open‐Sleeve Templates for Computer‐Assisted Implant Surgery at Healed or Extraction Sockets: An In Vitro Comparison to Closed‐Sleeve Guided System and Free‐Hand Approach,” Clinical Oral Implants Research 33, no. 7 (2022): 757–767. [DOI] [PubMed] [Google Scholar]
  • 85. Guentsch A., Bjork J., Saxe R., Han S., and Dentino A. R., “An In‐Vitro Analysis of the Accuracy of Different Guided Surgery Systems ‐ They Are Not All the Same,” Clinical Oral Implants Research 34, no. 5 (2023): 531–541. [DOI] [PubMed] [Google Scholar]
  • 86. Choi M., Romberg E., and Driscoll C. F., “Effects of Varied Dimensions of Surgical Guides on Implant Angulations,” Journal of Prosthetic Dentistry 92, no. 5 (2004): 463–469. [DOI] [PubMed] [Google Scholar]
  • 87. Koop R., Vercruyssen M., Vermeulen K., and Quirynen M., “Tolerance Within the Sleeve Inserts of Different Surgical Guides for Guided Implant Surgery,” Clinical Oral Implants Research 24, no. 6 (2013): 630–634. [DOI] [PubMed] [Google Scholar]
  • 88. Gourdache I., Salomó‐Coll O., Hernández‐Alfaro F., and Gargallo‐Albiol J., “Dental Implant Positioning Accuracy Using a Key or Keyless Static Fully Guided Surgical System: A Prospective Systematic Review and Meta‐Analysis,” International Journal of Prosthodontics 37, no. 2 (2024): 199–209. [DOI] [PubMed] [Google Scholar]
  • 89. Schneider D., Schober F., Grohmann P., Hammerle C. H., and Jung R. E., “In‐Vitro Evaluation of the Tolerance of Surgical Instruments in Templates for Computer‐Assisted Guided Implantology Produced by 3‐D Printing,” Clinical Oral Implants Research 26, no. 3 (2015): 320–325. [DOI] [PubMed] [Google Scholar]
  • 90. Wegmüller L., Halbeisen F., Sharma N., Kühl S., and Thieringer F. M., “Consumer vs. High‐End 3D Printers for Guided Implant Surgery‐An In Vitro Accuracy Assessment Study of Different 3D Printing Technologies,” Journal of Clinical Medicine 10, no. 21 (2021): 4894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 91. Pessoa R., Siqueira R., Li J., et al., “The Impact of Surgical Guide Fixation and Implant Location on Accuracy of Static Computer‐Assisted Implant Surgery,” Journal of Prosthodontics 31, no. 2 (2022): 155–164. [DOI] [PubMed] [Google Scholar]
  • 92. D'Haese J., van de Velde T., Elaut L., and De Bruyn H., “A Prospective Study on the Accuracy of Mucosally Supported Stereolithographic Surgical Guides in Fully Edentulous Maxillae,” Clinical Implant Dentistry and Related Research 14, no. 2 (2012): 293–303. [DOI] [PubMed] [Google Scholar]
  • 93. Cassetta M., Giansanti M., di Mambro A., and Stefanelli L. V., “Accuracy of Positioning of Implants Inserted Using a Mucosa‐Supported Stereolithographic Surgical Guide in the Edentulous Maxilla and Mandible,” International Journal of Oral & Maxillofacial Implants 29, no. 5 (2014): 1071–1078. [DOI] [PubMed] [Google Scholar]
  • 94. Khalil R. A., Ghosn N., Mokbel N., Chakar C., and Naaman N., “Key Factors for a Successful Surgical Guide: A Prospective Pilot Study,” Journal of Oral and Maxillofacial Radiology 8, no. 3 (2020): 47. [Google Scholar]
  • 95. Török G., Gombocz P., Bognár E., et al., “Effects of Disinfection and Sterilization on the Dimensional Changes and Mechanical Properties of 3D Printed Surgical Guides for Implant Therapy—Pilot Study,” BMC Oral Health 20, no. 1 (2020): 19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 96. Lim J. H., Bayarsaikhan E., Shin S. H., Nam N. E., Shim J. S., and Kim J. E., “Effects of Groove Sealing of the Posterior Occlusal Surface and Offset of the Internal Surface on the Internal Fit and Accuracy of Implant Placements Using 3D‐Printed Surgical Guides: An In Vitro Study,” Polymers (Basel) 13, no. 8 (2021): 1236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 97. Wu Y. T., Papaspyridakos P., Kang K., Finkelman M., Kudara Y., and de Souza A. B., “Accuracy of Different Surgical Guide Designs for Static Computer‐Assisted Implant Surgery: An In Vitro Study,” Journal of Oral Implantology 48, no. 5 (2022): 351–357. [DOI] [PubMed] [Google Scholar]
  • 98. Nocini P. F., Castellani R., Zanotti G., Bertossi D., Luciano U., and De Santis D., “The Use of Computer‐Guided Flapless Dental Implant Surgery (NobelGuide) and Immediate Function to Support a Fixed Full‐Arch Prosthesis in Fresh‐Frozen Homologous Patients With Bone Grafts,” Journal of Craniofacial Surgery 24, no. 6 (2013): e551–e558. [DOI] [PubMed] [Google Scholar]
  • 99. Amorfini L., Migliorati M., Drago S., and Silvestrini‐Biavati A., “Immediately Loaded Implants in Rehabilitation of the Maxilla: A Two‐Year Randomized Clinical Trial of Guided Surgery Versus Standard Procedure,” Clinical Implant Dentistry and Related Research 19, no. 2 (2017): 280–295. [DOI] [PubMed] [Google Scholar]
  • 100. Younes F., Eghbali A., de Bruyckere T., Cleymaet R., and Cosyn J., “A Randomized Controlled Trial on the Efficiency of Free‐Handed, Pilot‐Drill Guided and Fully Guided Implant Surgery in Partially Edentulous Patients,” Clinical Oral Implants Research 30, no. 2 (2019): 131–138. [DOI] [PubMed] [Google Scholar]
  • 101. Pozzi A., Tallarico M., Marchetti M., Scarfò B., and Esposito M., “Computer‐Guided Versus Free‐Hand Placement of Immediately Loaded Dental Implants: 1‐Year Post‐Loading Results of a Multicentre Randomised Controlled Trial,” European Journal of Oral Implantology 7, no. 3 (2014): 229–242. [PubMed] [Google Scholar]
  • 102. Schneider D., Sancho‐Puchades M., Schober F., Thoma D., Hämmerle C., and Jung R., “A Randomized Controlled Clinical Trial Comparing Conventional and Computer‐Assisted Implant Planning and Placement in Partially Edentulous Patients. Part 3: Time and Cost Analyses,” International Journal of Periodontics & Restorative Dentistry 39, no. 3 (2019): e71–e82. [DOI] [PubMed] [Google Scholar]
  • 103. Engkawong S., Mattheos N., Pisarnturakit P. P., Pimkhaokham A., and Subbalekha K., “Comparing Patient‐Reported Outcomes and Experiences Among Static, Dynamic Computer‐Aided, and Conventional Freehand Dental Implant Placement: A Randomized Clinical Trial,” Clinical Implant Dentistry and Related Research 23, no. 5 (2021): 660–670. [DOI] [PubMed] [Google Scholar]
  • 104. Kaewsiri D., Panmekiate S., Subbalekha K., Mattheos N., and Pimkhaokham A., “The Accuracy of Static vs. Dynamic Computer‐Assisted Implant Surgery in Single Tooth Space: A Randomized Controlled Trial,” Clinical Oral Implants Research 30, no. 6 (2019): 505–514. [DOI] [PubMed] [Google Scholar]
  • 105. van de Velde T., Sennerby L., and de Bruyn H., “The Clinical and Radiographic Outcome of Implants Placed in the Posterior Maxilla With a Guided Flapless Approach and Immediately Restored With a Provisional Rehabilitation: A Randomized Clinical Trial,” Clinical Oral Implants Research 21, no. 11 (2010): 1223–1233. [DOI] [PubMed] [Google Scholar]
  • 106. Joda T., Derksen W., Wittneben J. G., and Kuehl S., “Static Computer‐Aided Implant Surgery (s‐CAIS) Analysing Patient‐Reported Outcome Measures (PROMs), Economics and Surgical Complications: A Systematic Review,” Clinical Oral Implants Research 29, no. Suppl 16 (2018): 359–373. [DOI] [PubMed] [Google Scholar]
  • 107. Yeo X. H., Uei L. J., Yi M., et al., “Computer‐Assisted Implant Surgery: Patients' Experience and Perspectives,” Clinical and Experimental Dental Research 11, no. 3 (2025): e70143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 108. Youk S. Y., Lee J. H., Park J. M., et al., “A Survey of the Satisfaction of Patients Who Have Undergone Implant Surgery With and Without Employing a Computer‐Guided Implant Surgical Template,” Journal of Advanced Prosthodontics 6, no. 5 (2014): 395–405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 109. Sancho‐Puchades M., Alfaro F. H., Naenni N., Jung R., Hämmerle C., and Schneider D., “A Randomized Controlled Clinical Trial Comparing Conventional and Computer‐Assisted Implant Planning and Placement in Partially Edentulous Patients. Part 2: Patient Related Outcome Measures,” International Journal of Periodontics & Restorative Dentistry 39, no. 4 (2019): e99–e110. [DOI] [PubMed] [Google Scholar]
  • 110. Almahrous G., David‐Tchouda S., Sissoko A., Rancon N., Bosson J. L., and Fortin T., “Patient‐Reported Outcome Measures (PROMs) for Two Implant Placement Techniques in Sinus Region (Bone Graft Versus Computer‐Aided Implant Surgery): A Randomized Prospective Trial,” International Journal of Environmental Research and Public Health 17, no. 9 (2020): 2990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 111. Søndergaard K., Hosseini M., Storgård Jensen S., Spin‐Neto R., and Gotfredsen K., “Fully Versus Conventionally Guided Implant Placement by Dental Students: A Randomized Controlled Trial,” Clinical Oral Implants Research 32, no. 9 (2021): 1072–1084. [DOI] [PubMed] [Google Scholar]
  • 112. Fortin T., Bosson J. L., Isidori M., and Blanchet E., “Effect of Flapless Surgery on Pain Experienced in Implant Placement Using an Image‐Guided System,” International Journal of Oral & Maxillofacial Implants 21, no. 2 (2006): 298–304. [PubMed] [Google Scholar]
  • 113. Vercruyssen M., van de Wiele G., Teughels W., Naert I., Jacobs R., and Quirynen M., “Implant‐ and Patient‐Centred Outcomes of Guided Surgery, a 1‐Year Follow‐Up: An RCT Comparing Guided Surgery With Conventional Implant Placement,” Journal of Clinical Periodontology 41, no. 12 (2014): 1154–1160. [DOI] [PubMed] [Google Scholar]
  • 114. Nkenke E., Eitner S., Radespiel‐Tröger M., Vairaktaris E., Neukam F. W., and Fenner M., “Patient‐Centred Outcomes Comparing Transmucosal Implant Placement With an Open Approach in the Maxilla: A Prospective, Non‐Randomized Pilot Study,” Clinical Oral Implants Research 18, no. 2 (2007): 197–203. [DOI] [PubMed] [Google Scholar]
  • 115. Cassetta M., Altieri F., Giansanti M., Bellardini M., Brandetti G., and Piccoli L., “Is There a Learning Curve in Static Computer‐Assisted Implant Surgery? A Prospective Clinical Study,” International Journal of Oral and Maxillofacial Surgery 49, no. 10 (2020): 1335–1342. [DOI] [PubMed] [Google Scholar]
  • 116. Werny J. G., Fan S., Diaz L., et al., “Evaluation of the Accuracy, Surgical Time, and Learning Curve of Freehand, Static, and Dynamic Computer‐Assisted Implant Surgery in an In Vitro Study,” Clinical Oral Implants Research 36 (2025): 555–565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 117. Wu D., Zhou L., Yang J., et al., “Accuracy of Dynamic Navigation Compared to Static Surgical Guide for Dental Implant Placement,” International Journal of Implant Dentistry 6, no. 1 (2020): 78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 118. Hinckfuss S., Conrad H., Lin L.‐S., Lunos S., and Seong W. J., “Effect of Surgical Guide Design and Surgeon's Experience on the Accuracy of Implant Placement,” Journal of Oral Implantology 38 (2010): 311–323. [DOI] [PubMed] [Google Scholar]
  • 119. Yao C. J., Chow J., Choi W. W. S., and Mattheos N., “Measuring the Impact of Simulation Practice on the Spatial Representation Ability of Dentists by Means of Impacted Mandibular Third Molar (IMTM) Surgery on 3D Printed Models,” European Journal of Dental Education 23, no. 3 (2019): 332–343. [DOI] [PubMed] [Google Scholar]
  • 120. Uei L. J., Yeo X. H., Leung Y. Y., Pelekos G., Nawas B. A., and Mattheos N., “Computer‐Assisted Implant Surgery: Implications for Teaching, Learning, and Educational Strategies,” Cllinical and Experimental Dental Research 11, no. 4 (2025): e70197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 121. Wang W., Zhuang M., Li S., et al., “Exploring Training Dental Implant Placement Using Static or Dynamic Devices Among Dental Students,” European Journal of Dental Education 27, no. 3 (2023): 438–448. [DOI] [PubMed] [Google Scholar]
  • 122. Heng S., Arunjaroensuk S., Pozzi A., Damrongsirirat N., Pimkhaokham A., and Mattheos N., “Comparing Medium to Long‐Term Esthetic, Clinical, and Patient‐Reported Outcomes Between Freehand and Computer‐Assisted Dental Implant Placement: A Cross‐Sectional Study,” Journal of Esthetic and Restorative Dentistry 37, no. 4 (2025): 834–843, 10.1111/jerd.13345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 123. Gargallo‐Albiol J., Barootchi S., Salomó‐Coll O., and Wang H.‐l., “Advantages and Disadvantages of Implant Navigation Surgery. A Systematic Review,” Annals of Anatomy 225 (2019): 1–10. [DOI] [PubMed] [Google Scholar]
  • 124. Tatakis D. N., Chien H. H., and Parashis A. O., “Guided Implant Surgery Risks and Their Prevention,” Periodontology 2000 81, no. 1 (2000): 194–208. [DOI] [PubMed] [Google Scholar]
  • 125. Saxena V., Dhawan P., and Rani S., “Effect of Guided Implant Drilling on Bone Temperature Changes During Implant Osteotomy: A Comprehensive Systematic Review,” Cureus 16, no. 9 (2024): e70216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 126. Block M. S. and Emery R. W., “Static or Dynamic Navigation for Implant Placement—Choosing the Method of Guidance,” Journal of Oral and Maxillofacial Surgery 74, no. 2 (2016): 269–277. [DOI] [PubMed] [Google Scholar]
  • 127. Strauss F. J., Park J. Y., Lee J. S., et al., “Wide Restorative Emergence Angle Increases Marginal Bone Loss and Impairs Integrity of the Junctional Epithelium of the Implant Supracrestal Complex: A Preclinical Study,” Journal of Clinical Periodontology 51, no. 12 (2024): 1677–1687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 128. Lorwicheanrung J., Mahardawi B., Arunjaroensuk S., Kaboosaya B., Mattheos N., and Pimkhaokham A., “The Accuracy of Implant Placement Using a Combination of Static and Dynamic Computer‐Assisted Implant Surgery in Fully Edentulous Arches: A Prospective Controlled Clinical Study,” Clinical Oral Implants Research 35, no. 8 (2024): 841–853. [DOI] [PubMed] [Google Scholar]
  • 129. Ochandiano S., García‐Mato D., Gonzalez‐Alvarez A., et al., “Computer‐Assisted Dental Implant Placement Following Free Flap Reconstruction: Virtual Planning, CAD/CAM Templates, Dynamic Navigation and Augmented Reality,” Frontiers in Oncology 11 (2022): 2021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 130. Sun T. M., Lee H. E., and Lan T. H., “Comparing Accuracy of Implant Installation With a Navigation System (NS), a Laboratory Guide (LG), NS With LG, and Freehand Drilling,” International Journal of Environmental Research and Public Health 17, no. 6 (2020): 2107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 131. Kernen F., Kramer J., Wanner L., Wismeijer D., Nelson K., and Flügge T., “A Review of Virtual Planning Software for Guided Implant Surgery ‐ Data Import and Visualization, Drill Guide Design and Manufacturing,” BMC Oral Health 20, no. 1 (2020): 251. [DOI] [PMC free article] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Data Availability Statement

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.


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