TABLE 1.

Mutants of the TEM-1 β-lactamase conferring resistance to ceftazidime

Residue in TEM-1	Amino acid substitution
	Mutant 1	Mutant 2	Mutant 3	Mutant 4	Mutant 5	Mutant 6
Ala42	Gly	Gly	Gly	Gly	Gly	Gly
Ile47	Val	Val	Val	Val	Val	Val
Glu104	Lys	Lys	Lys	Lys	Lys	Lys
Pro167	Ser	Ser		Ser	Ser
Leu169	Pro			Pro	Pro
Ala184	Val			Val
Gly238	Ser		Ser		Ser
Glu240	Gly		Gly		Gly
Ser268	Gly	Gly	Gly	Gly		Gly
Asn276	Asp	Asp	Asp	Asp	Asp	Asp
Lys288	Glu